Misoprostol en la Inducción del Parto en Mujeres Obesas y Resultados Obstétricos. Revisión sistemática
Palabras clave:
inducción del trabajo de parto, obesidad, misoprostol
Resumen
El misoprostol se utiliza como inductor del trabajo de parto, su dosis en obesidad no se ha establecido. El objetivo de estudio fue examinar la eficacia del misoprostol para la inducción del trabajo de parto en embarazadas con obesidad mediante una revisión sistemática, se incluyeron estudios experimentales y observacionales. La búsqueda se realizó en PubMed, Wiley y Springer. Tres revisores seleccionaron los estudios. Las herramientas Rayyan y Study Quality Assessment permitieron clasificar y valorar el riesgo de sesgo. De los 105 registros identificados, se incluyeron 10, con 9.672 embarazadas con indicación de inducción de labor de parto. Se observó una relación inversamente proporcional entre el indice de masa corporal y número de dosis de misoprostol. La dosis de misoprostol 25 microgramos vía vaginal cada 6 horas es una alternativa segura para la inducción del trabajo de parto en pacientes con obesidad, este método condujo a más partos vaginales frente a la inducción dinoprostona o sonda foley. No se observaron resultados neonatales adversos relacionados con misoprostol. La inducción del parto con misoprostol 25 microgramos vía vaginal en pacientes con obesidad se asoció con mejores resultados obstétricos y neonatales. Sin embargo, dosis mayores podrían considerarse individualizando los riesgos.
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ACOG Practice Bulletin No. 107: Induction of Labor. (2009). Obstetrics & Gynecology, 114(2), 386-397. https://doi.org/10.1097/AOG.0b013e3181b48ef5
Ashraf, R., Maxwell, C., & D’Souza, R. (2022). Induction of labour in pregnant individuals with obesity. Best Practice & Research Clinical Obstetrics & Gynaecology, 79, 70-80. https://doi.org/10.1016/j.bpobgyn.2021.12.004
Bjorklund, J., Wiberg-Itzel, E., & Wallstrom, T. (2022). Is there an increased risk of cesarean section in obese women after induction of labor? A retrospective cohort study. PLOS ONE, 17(2), e0263685. https://doi.org/10.1371/journal.pone.0263685
Croll, D. M. R., De Vaan, M. D. T., Moes, S. L., Bloemenkamp, K. W. M., Ten Eikelder, M. L. G., De Heus, R., Jozwiak, M., Kooiman, J., Mol, B. W., Verhoeven, C. J. M., & De Boer, M. A. (2024). Methods of induction of labor in women with obesity: A secondary analysis of two multicenter randomized controlled trials. Acta Obstetricia et Gynecologica Scandinavica, 103(3), 470-478. https://doi.org/10.1111/aogs.14737
Drummond, R., Patel, M., Myers, M., Ritter, A., Hurvitz, J. A., Goetzinger, K. R., & Crimmins, S. D. (2022). Class III obesity is an independent risk factor for unsuccessful induction of labor. AJOG Global Reports, 2(4), 100109. https://doi.org/10.1016/j.xagr.2022.100109
Ellis, J. A., Brown, C. M., Barger, B., & Carlson, N. S. (2019). Influence of Maternal Obesity on Labor Induction: A Systematic Review and Meta‐Analysis. Journal of Midwifery & Women’s Health, 64(1), 55-67. https://doi.org/10.1111/jmwh.12935
FIGO. (2023). FIGO Mifepristone & Misoprostol and Misoprostol Only Dosing Charts 2023. https://www.figo.org/figo-mifepristone-misoprostol-and-misoprostol-only-dosing-charts-2023
Gill, P., Lende, M. N., & Van Hook, J. W. (2024). Induction of Labor. En StatPearls. StatPearls Publishing. http://www.ncbi.nlm.nih.gov/books/NBK459264/
Hautakangas, T., Uotila, J., Kontiainen, J., Huhtala, H., & Palomäki, O. (2022). Impact of obesity on uterine contractile activity during labour: A blinded analysis of a randomised controlled trial cohort. BJOG: An International Journal of Obstetrics & Gynaecology, 129(10), 1790-1797. https://doi.org/10.1111/1471-0528.17128
Helmig, R. B., Brogaard, L., & Hvidman, L. (2021). Women’s body mass index and oral administration of Misoprostol for induction of labor – A retrospective cohort study. Obesity Research & Clinical Practice, 15(5), 509-511. https://doi.org/10.1016/j.orcp.2021.09.001
Jaiswal, S., Kyejo, W., & Kilewo, C. (2024). Maternal and neonatal outcome in pregnant women undergone induction of labor at Muhimbili National Hospital, Dar Es Salaam, Tanzania. BMC Pregnancy and Childbirth, 24(1), 387. https://doi.org/10.1186/s12884-024-06578-w
Kerr, R. S., Kumar, N., Williams, M. J., Cuthbert, A., Aflaifel, N., Haas, D. M., & Weeks, A. D. (2021). Low-dose oral misoprostol for induction of labour. Cochrane Database of Systematic Reviews, 2021(6). https://doi.org/10.1002/14651858.CD014484
Kissler, K., & Hurt, K. J. (2023). The Pathophysiology of Labor Dystocia: Theme with Variations. Reproductive Sciences, 30(3), 729-742. https://doi.org/10.1007/s43032-022-01018-6
Maged, A. M., El-Semary, A. M., Marie, H. M., Belal, D. S., Hany, A., Taymour, M. A., Omran, E. F., Elbaradie, S. M. Y., & Mohamed, M. A. K. (2019). Effect of maternal obesity on labor induction in postdate pregnancy. Archives of Gynecology and Obstetrics, 298(1), 45-50. https://doi.org/10.1007/s00404-018-4767-8
Maggi, C., Mazzoni, G., Gerosa, V., Fratelli, N., Prefumo, F., Sartori, E., & Lojacono, A. (2019). Labor induction with misoprostol vaginal insert compared with dinoprostone vaginal insert. Acta Obstetricia et Gynecologica Scandinavica, 98(10), 1268-1273.
https://doi.org/10.1111/aogs.13667
Melo, G., Aguilar-Farias, N., López Barrera, E., Chomalí, L., Moz-Christofoletti, M. A., Salgado, J. C., Swensson, L. J., & Caro, J. C. (2023). Structural responses to the obesity epidemic in Latin America: What are the next steps for food and physical activity policies? The Lancet Regional Health - Americas, 21, 100486. https://doi.org/10.1016/j.lana.2023.100486
Morris, J. L., Winikoff, B., Dabash, R., Weeks, A., Faundes, A., Gemzell‐Danielsson, K., Kapp, N., Castleman, L., Kim, C., Ho, P. C., & Visser, G. H. A. (2017). FIGO’s updated recommendations for misoprostol used alone in gynecology and obstetrics. International Journal of Gynecology & Obstetrics, 138(3), 363-366. https://doi.org/10.1002/ijgo.12181
NHLBI. (2024). Study Quality Assessment Tools. https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools
Ouzzani, M., Hammady, H., Fedorowicz, Z., & Elmagarmid, A. (2016). Rayyan—A web and mobile app for systematic reviews. Systematic Reviews, 5(1), 210. https://doi.org/10.1186/s13643-016-0384-4
Page, M. J., Moher, D., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., McDonald, S., … McKenzie, J. E. (2021). PRISMA 2020 explanation and elaboration: Updated guidance and exemplars for reporting systematic reviews. BMJ (Clinical Research Ed.), 372, n160. https://doi.org/10.1136/bmj.n160
Ruhstaller, K. (2015). Induction of labor in the obese patient. Seminars in Perinatology, 39(6), 437-440. https://doi.org/10.1053/j.semperi.2015.07.003
Saucedo, A. M., Alvarez, M., Macones, G. A., Cahill, A. G., & Harper, L. M. (2024). Optimal misoprostol dosing among patients with a body mass index greater than 30: A randomized controlled trial. American Journal of Obstetrics and Gynecology, 230(5), 565.e1-565.e16. https://doi.org/10.1016/j.ajog.2024.02.004
Sfregola, G., Sfregola, P., Ruta, F., Zendoli, F., Musicco, A., Garzon, S., Uccella, S., Etrusco, A., Chiantera, V., Terzic, S., Giannini, A., & Laganà, A. S. (2023). Effect of maternal age and body mass index on induction of labor with oral misoprostol for premature rupture of membrane at term: A retrospective cross-sectional study. Open Medicine, 18(1), 20230747. https://doi.org/10.1515/med-2023-0747
Soni, S., Pappas, K., Lesser, M. L., Blitz, M. J., Augustine, S. A., & Rochelson, B. (2020). Is vaginal misoprostol more effective than oral misoprostol for cervical ripening in obese women? The Journal of Maternal-Fetal & Neonatal Medicine, 33(20), 3476-3483. https://doi.org/10.1080/14767058.2019.1575684
Taliento, C., Manservigi, M., Tormen, M., Cappadona, R., Piccolotti, I., Salvioli, S., Scutiero, G., & Greco, P. (2023). Safety of misoprostol vs dinoprostone for induction of labor: A systematic review and meta-analysis. European Journal of Obstetrics & Gynecology and Reproductive Biology, 289, 108-128. https://doi.org/10.1016/j.ejogrb.2023.08.382
Tian, S., Wang, L., Han, Y., Liu, Y., Li, F.-Q., & Jin, X.-H. (2024). Efficacy and safety of oral and vaginal administration of misoprostol for induction of labor in high-risk obese pregnant women with hypertension or diabetes mellitus. The Journal of Maternal-Fetal & Neonatal Medicine, 37(1), 2327573. https://doi.org/10.1080/14767058.2024.2327573
Varlas, V. N., Bostan, G., Nasui, B. A., Bacalbasa, N., & Pop, A. L. (2021). Is Misoprostol Vaginal Insert Safe for the Induction of Labor in High-Risk Pregnancy Obese Women? Healthcare, 9(4), 464. https://doi.org/10.3390/healthcare9040464
Vorontsova, Y., Haas, D. M., Flannery, K., Masters, A. R., Silva, L. L., Pierson, R. C., Yeley, B., Hogg, G., Guise, D., Heathman, M., & Quinney, S. K. (2022). Pharmacokinetics of vaginal versus buccal misoprostol for labor induction at term. Clinical and Translational Science, 15(8), 1937-1945. https://doi.org/10.1111/cts.13306
Wendremaire, M., Lopez, T. E., Barrichon, M., Zhang, H., Hadi, T., Ye, X.-Y., Neiers, F., Bardou, M., Sagot, P., Garrido, C., & Lirussi, F. (2022). Leptin-Induced HLA-G Inhibits Myometrial Contraction and Differentiation. Cells, 11(6), 954. https://doi.org/10.3390/cells11060954
Young, D. C., Delaney, T., Armson, B. A., & Fanning, C. (2020). Oral misoprostol, low dose vaginal misoprostol, and vaginal dinoprostone for labor induction: Randomized controlled trial. PLOS ONE, 15(1), e0227245. https://doi.org/10.1371/journal.pone.0227245
Ashraf, R., Maxwell, C., & D’Souza, R. (2022). Induction of labour in pregnant individuals with obesity. Best Practice & Research Clinical Obstetrics & Gynaecology, 79, 70-80. https://doi.org/10.1016/j.bpobgyn.2021.12.004
Bjorklund, J., Wiberg-Itzel, E., & Wallstrom, T. (2022). Is there an increased risk of cesarean section in obese women after induction of labor? A retrospective cohort study. PLOS ONE, 17(2), e0263685. https://doi.org/10.1371/journal.pone.0263685
Croll, D. M. R., De Vaan, M. D. T., Moes, S. L., Bloemenkamp, K. W. M., Ten Eikelder, M. L. G., De Heus, R., Jozwiak, M., Kooiman, J., Mol, B. W., Verhoeven, C. J. M., & De Boer, M. A. (2024). Methods of induction of labor in women with obesity: A secondary analysis of two multicenter randomized controlled trials. Acta Obstetricia et Gynecologica Scandinavica, 103(3), 470-478. https://doi.org/10.1111/aogs.14737
Drummond, R., Patel, M., Myers, M., Ritter, A., Hurvitz, J. A., Goetzinger, K. R., & Crimmins, S. D. (2022). Class III obesity is an independent risk factor for unsuccessful induction of labor. AJOG Global Reports, 2(4), 100109. https://doi.org/10.1016/j.xagr.2022.100109
Ellis, J. A., Brown, C. M., Barger, B., & Carlson, N. S. (2019). Influence of Maternal Obesity on Labor Induction: A Systematic Review and Meta‐Analysis. Journal of Midwifery & Women’s Health, 64(1), 55-67. https://doi.org/10.1111/jmwh.12935
FIGO. (2023). FIGO Mifepristone & Misoprostol and Misoprostol Only Dosing Charts 2023. https://www.figo.org/figo-mifepristone-misoprostol-and-misoprostol-only-dosing-charts-2023
Gill, P., Lende, M. N., & Van Hook, J. W. (2024). Induction of Labor. En StatPearls. StatPearls Publishing. http://www.ncbi.nlm.nih.gov/books/NBK459264/
Hautakangas, T., Uotila, J., Kontiainen, J., Huhtala, H., & Palomäki, O. (2022). Impact of obesity on uterine contractile activity during labour: A blinded analysis of a randomised controlled trial cohort. BJOG: An International Journal of Obstetrics & Gynaecology, 129(10), 1790-1797. https://doi.org/10.1111/1471-0528.17128
Helmig, R. B., Brogaard, L., & Hvidman, L. (2021). Women’s body mass index and oral administration of Misoprostol for induction of labor – A retrospective cohort study. Obesity Research & Clinical Practice, 15(5), 509-511. https://doi.org/10.1016/j.orcp.2021.09.001
Jaiswal, S., Kyejo, W., & Kilewo, C. (2024). Maternal and neonatal outcome in pregnant women undergone induction of labor at Muhimbili National Hospital, Dar Es Salaam, Tanzania. BMC Pregnancy and Childbirth, 24(1), 387. https://doi.org/10.1186/s12884-024-06578-w
Kerr, R. S., Kumar, N., Williams, M. J., Cuthbert, A., Aflaifel, N., Haas, D. M., & Weeks, A. D. (2021). Low-dose oral misoprostol for induction of labour. Cochrane Database of Systematic Reviews, 2021(6). https://doi.org/10.1002/14651858.CD014484
Kissler, K., & Hurt, K. J. (2023). The Pathophysiology of Labor Dystocia: Theme with Variations. Reproductive Sciences, 30(3), 729-742. https://doi.org/10.1007/s43032-022-01018-6
Maged, A. M., El-Semary, A. M., Marie, H. M., Belal, D. S., Hany, A., Taymour, M. A., Omran, E. F., Elbaradie, S. M. Y., & Mohamed, M. A. K. (2019). Effect of maternal obesity on labor induction in postdate pregnancy. Archives of Gynecology and Obstetrics, 298(1), 45-50. https://doi.org/10.1007/s00404-018-4767-8
Maggi, C., Mazzoni, G., Gerosa, V., Fratelli, N., Prefumo, F., Sartori, E., & Lojacono, A. (2019). Labor induction with misoprostol vaginal insert compared with dinoprostone vaginal insert. Acta Obstetricia et Gynecologica Scandinavica, 98(10), 1268-1273.
https://doi.org/10.1111/aogs.13667
Melo, G., Aguilar-Farias, N., López Barrera, E., Chomalí, L., Moz-Christofoletti, M. A., Salgado, J. C., Swensson, L. J., & Caro, J. C. (2023). Structural responses to the obesity epidemic in Latin America: What are the next steps for food and physical activity policies? The Lancet Regional Health - Americas, 21, 100486. https://doi.org/10.1016/j.lana.2023.100486
Morris, J. L., Winikoff, B., Dabash, R., Weeks, A., Faundes, A., Gemzell‐Danielsson, K., Kapp, N., Castleman, L., Kim, C., Ho, P. C., & Visser, G. H. A. (2017). FIGO’s updated recommendations for misoprostol used alone in gynecology and obstetrics. International Journal of Gynecology & Obstetrics, 138(3), 363-366. https://doi.org/10.1002/ijgo.12181
NHLBI. (2024). Study Quality Assessment Tools. https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools
Ouzzani, M., Hammady, H., Fedorowicz, Z., & Elmagarmid, A. (2016). Rayyan—A web and mobile app for systematic reviews. Systematic Reviews, 5(1), 210. https://doi.org/10.1186/s13643-016-0384-4
Page, M. J., Moher, D., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., McDonald, S., … McKenzie, J. E. (2021). PRISMA 2020 explanation and elaboration: Updated guidance and exemplars for reporting systematic reviews. BMJ (Clinical Research Ed.), 372, n160. https://doi.org/10.1136/bmj.n160
Ruhstaller, K. (2015). Induction of labor in the obese patient. Seminars in Perinatology, 39(6), 437-440. https://doi.org/10.1053/j.semperi.2015.07.003
Saucedo, A. M., Alvarez, M., Macones, G. A., Cahill, A. G., & Harper, L. M. (2024). Optimal misoprostol dosing among patients with a body mass index greater than 30: A randomized controlled trial. American Journal of Obstetrics and Gynecology, 230(5), 565.e1-565.e16. https://doi.org/10.1016/j.ajog.2024.02.004
Sfregola, G., Sfregola, P., Ruta, F., Zendoli, F., Musicco, A., Garzon, S., Uccella, S., Etrusco, A., Chiantera, V., Terzic, S., Giannini, A., & Laganà, A. S. (2023). Effect of maternal age and body mass index on induction of labor with oral misoprostol for premature rupture of membrane at term: A retrospective cross-sectional study. Open Medicine, 18(1), 20230747. https://doi.org/10.1515/med-2023-0747
Soni, S., Pappas, K., Lesser, M. L., Blitz, M. J., Augustine, S. A., & Rochelson, B. (2020). Is vaginal misoprostol more effective than oral misoprostol for cervical ripening in obese women? The Journal of Maternal-Fetal & Neonatal Medicine, 33(20), 3476-3483. https://doi.org/10.1080/14767058.2019.1575684
Taliento, C., Manservigi, M., Tormen, M., Cappadona, R., Piccolotti, I., Salvioli, S., Scutiero, G., & Greco, P. (2023). Safety of misoprostol vs dinoprostone for induction of labor: A systematic review and meta-analysis. European Journal of Obstetrics & Gynecology and Reproductive Biology, 289, 108-128. https://doi.org/10.1016/j.ejogrb.2023.08.382
Tian, S., Wang, L., Han, Y., Liu, Y., Li, F.-Q., & Jin, X.-H. (2024). Efficacy and safety of oral and vaginal administration of misoprostol for induction of labor in high-risk obese pregnant women with hypertension or diabetes mellitus. The Journal of Maternal-Fetal & Neonatal Medicine, 37(1), 2327573. https://doi.org/10.1080/14767058.2024.2327573
Varlas, V. N., Bostan, G., Nasui, B. A., Bacalbasa, N., & Pop, A. L. (2021). Is Misoprostol Vaginal Insert Safe for the Induction of Labor in High-Risk Pregnancy Obese Women? Healthcare, 9(4), 464. https://doi.org/10.3390/healthcare9040464
Vorontsova, Y., Haas, D. M., Flannery, K., Masters, A. R., Silva, L. L., Pierson, R. C., Yeley, B., Hogg, G., Guise, D., Heathman, M., & Quinney, S. K. (2022). Pharmacokinetics of vaginal versus buccal misoprostol for labor induction at term. Clinical and Translational Science, 15(8), 1937-1945. https://doi.org/10.1111/cts.13306
Wendremaire, M., Lopez, T. E., Barrichon, M., Zhang, H., Hadi, T., Ye, X.-Y., Neiers, F., Bardou, M., Sagot, P., Garrido, C., & Lirussi, F. (2022). Leptin-Induced HLA-G Inhibits Myometrial Contraction and Differentiation. Cells, 11(6), 954. https://doi.org/10.3390/cells11060954
Young, D. C., Delaney, T., Armson, B. A., & Fanning, C. (2020). Oral misoprostol, low dose vaginal misoprostol, and vaginal dinoprostone for labor induction: Randomized controlled trial. PLOS ONE, 15(1), e0227245. https://doi.org/10.1371/journal.pone.0227245
Publicado
2024-11-27
Cómo citar
Vega Cuadrado, D. F., Delgado Astudillo, E. P., & Prieto Fuenmayor, C. F. (2024). Misoprostol en la Inducción del Parto en Mujeres Obesas y Resultados Obstétricos. Revisión sistemática. Ciencia Latina Revista Científica Multidisciplinar, 8(5), 10911-10929. https://doi.org/10.37811/cl_rcm.v8i5.14476
Número
Sección
Ciencias de la Salud
Derechos de autor 2024 Diego Fernando Vega Cuadrado, Erika Paola Delgado Astudillo, Carem Franscelys Prieto Fuenmayor
Esta obra está bajo licencia internacional Creative Commons Reconocimiento 4.0.
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