MicroARNs como biomarcadores pronósticos de Diabetes Mellitus tipo 2. Una revisión sistemática
Resumen
La Diabetes Mellitus tipo 2 (DM2), es una enfermedad multifactorial, causada por una desregulación de la homeostasis de la glucosa, que se asocia a factores genéticos, sociales y medioambientales. En la acualidad se considera una epidemia creciente, donde 527 millones de personas alrededor del mundo tienen DM y en los próximos 25 años la prevalencia mundial aumentará alrededor de un 46%. Por ende, es de vital importancia contar con nuevos biomarcadores que permitan un diagnóstico oportuno o para pronósticar el riesgo de desarrollo de la enfermedad. En este sentido, se realizó una revisión sistemática de los principales microARN que puedieran ser utilizados como biomarcadores pronósticos de DM2. Las búsquedas bibliográficas se realizaron utilizando las bases de datos PubMed y Cochrane con el término “microARN and T2DM” y siguiendo los lineamientos de PRISMA 2020, se seleccionaron un total de 25 artículos, cuyos resultados y/o bibliografía permitían cumplir el objetivo propuesto, siendo catalogados como biomarcadores pronósticos los siguientes microARNs: miR-21, miR-122, miR-135a, miR-30a-5p, miR-375, miR-126.
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Derechos de autor 2025 Jorge Leonardo Carchipulla Garnica , Andrea Fernanda Jimbo Guillermo, Pedro Rosendo Chalma
Esta obra está bajo licencia internacional Creative Commons Reconocimiento 4.0.
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