Romero (Rosmarinus Officinalis L.) Y su Potencial Terapéutico en las Enfermedades Cardiovasculares: Una Revisión Bibliográfica
Resumen
Las enfermedades cardiovasculares (ECV) representadas en su gran mayoría por las enfermedades de las arterias coronarias son trastornos del corazón y los vasos sanguíneos que se ubican como la principal causa de muerte a nivel mundial. Una poderosa alternativa terapéutica frente a estas enfermedades debido a sus compuestos activos es R. officinalis L. (Romero), perteneciente a la familia de las Lamiaceae del género Rosmarinus la cual ha mostrado presentar propiedades antioxidantes, antinflamatorias, hipolipemiantes, hipoglucemiantes, antihipertensivas, antifibróticas, entre otras. Esta revisión tiene como objetivo sintetizar la evidencia científica publicada en la última década en las bases de datos Pubmed y Google Académico acerca del potencial terapéutico del Romero en las ECV siguiendo la metodología de las guías Prismas 2020. Se consultaron un total de 63 artículos, de ellos, 57 directamente relacionados con los efectos beneficiosos de la planta en la fisiopatogénesis de las enfermedades cardiovasculares. La mayoría de los estudios son preclínicos e in vitro, demostrando que aún son escasas las investigaciones clínicas sobre el tema, por lo que sugerimos ampliar las investigaciones en humanos, dado que pudiera representar en el futuro una caída importante en los niveles de morbimortalidad y discapacidad debido a estas patologías
Descargas
Citas
Alegría Herrera, E., Hernández Reséndiz, S., Román Aguirre, M., Sánchez Mendoza, A., & Pastelín Hernández, G. (2022). Rosmarinic acid attenuates hypertension and cardiac remodeling in myocardial infarcted rats through modulation of ACE/ACE2 balance. Biomedicine & Pharmacotherapy, 150, 113046. https://doi.org/10.1016/j.biopha.2022.113046
Ansari, P., Khan, J. T., Chowdhury, S., Reberio, A. D., Kumar, S., Seidel, V., Abdel-Wahab, Y. H. A., & Flatt, P. R. (2024). Plant-based diets and phytochemicals in the management of diabetes mellitus and prevention of its complications: A review. Nutrients, 16(21), 3709. https://doi.org/10.3390/nu16213709
Bao, T. Q., Li, Y., Qu, C., Zheng, Z. G., Yang, H., & Li, P. (2020). Antidiabetic effects and mechanisms of rosemary (Rosmarinus officinalis L.) and its phenolic components. The American Journal of Chinese Medicine, 48(6), 1353–1368. https://doi.org/10.1142/S0192415X20500664
Fang, Z., Lu, M., Huang, R., Wang, G., Yushanjiang, F., Jiang, X., & Li, J. (2024). Carnosol prevents cardiac remodeling and ventricular arrhythmias in pressure overload-induced heart failure mice. Phytotherapy Research, 38(7), 3763–3781. https://doi.org/10.1002/ptr.8213
Flores-Villa, E., Sáenz-Galindo, A., Castañeda-Facio, A. O., & Narro-Céspedes, R. I. (2020). Romero (Rosmarinus officinalis L.): Origen, importancia y generalidades de sus metabolitos secundarios. TIP Revista Especializada en Ciencias Químico-Biológicas, 23, 1–17. https://doi.org/10.22201/fesz.23958723e.2020.0.266
Garros Ferreira, L., Barbosa Évora, P. R., Kise Capellini, V., Afrodite Albuquerque, A., Menezes Carvalho, M. T., da Silva Gomes, R. A., Parolini, M. T., & Celotto, A. C. (2018). Efecto del ácido rosmarínico en la presión arterial en ratas normotensas e hipertensas: Papel de la ECA. Phytomedicine, 38, 158–165. https://doi.org/10.1016/j.phymed.2017.02.006
Gasparotto Junior, A., Lívero, F. A. D. R., & Acco, A. (2022). Biologically active products as therapeutic options for the treatment of cardiovascular diseases related to liver injury. Frontiers in Pharmacology, 13, 1041020. https://doi.org/10.3389/fphar.2022.1041020
Ghasemzadeh Rahbardar, M., & Hosseinzadeh, H. (2025). Toxicity and safety of rosemary (Rosmarinus officinalis): A comprehensive review. Naunyn-Schmiedeberg’s Archives of Pharmacology, 398, 9–23. https://doi.org/10.1007/s00210-024-03336-9
Habtemariam, S. (2023). Anti-inflammatory therapeutic mechanisms of natural products: Insight from rosemary diterpenes, carnosic acid and carnosol. Biomedicines, 11(2), 545. https://doi.org/10.3390/biomedicines11020545
Hu, S., Liu, B., Yang, M., Mao, S., Ju, H., Liu, Z., Huang, M., & Wu, G. (2023). Carnosic acid protects against doxorubicin-induced cardiotoxicity through enhancing the Nrf2/HO-1 pathway. Food & Function, 14(8), 3849–3862. https://doi.org/10.1039/d2fo03904d
International Diabetes Federation. (2021). IDF Diabetes Atlas (10th ed.). International Diabetes Federation.
Jia, G., Hill, M. A., & Sowers, J. R. (2018). Diabetic cardiomyopathy: An update of mechanisms contributing to this clinical entity. Circulation Research, 122(4), 624–638. https://doi.org/10.1161/CIRCRESAHA.117.311586
Jiang, Q., Han, Y., Gao, H., Tian, R., Li, P., & Wang, C. (2016). Ursolic acid–induced antiproliferative effects in primary rat vascular smooth muscle cells are associated with microRNA 21 inhibition and subsequent PTEN/PI3K suppression. European Journal of Pharmacology, 781, 69–75. https://doi.org/10.1016/j.ejphar.2016.04.001
Jiang, Y., Zheng, Z., Wang, J., Liao, Y., Jia, Z., Lin, W., Xu, D., Wang, J., Wu, G., Liang, G., & Ye, B. (2025). Carnosol mitigates Ang II–stimulated vascular injury and oxidative stress by directly binding to FAK and inhibiting its activation. Inflammopharmacology, 33(6), 3349–3362. https://doi.org/10.1007/s10787-025-01721-1
Karthik, D., & Ravikumar, S. (2011). Effect of rosmarinic acid on fructose fed hypertensive rats. Journal of Pharmacy Research, 4(3), 720–722.
Leng, S., Iwanowycz, S., Saaoud, F., et al. (2016). Ursolic acid enhances macrophage autophagy and attenuates atherogenesis. Journal of Lipid Research, 57(6), 1006–1016. https://doi.org/10.1194/jlr.M065888
Li, L., Tian, J. W., & Liang, X. G. (2008). Rosmarinic acid–induced regression of atherosclerosis through lipid metabolism regulation and anti inflammatory actions. Journal of Molecular and Cellular Cardiology, 44(4), 719. https://doi.org/10.1016/j.yjmcc.2008.02.021
Liang, Y. C., Wan, T. J., Wei, T. W., Zhang, J., & Li, Y. F. (2025). Potential role of rosemary in cardiovascular disease therapies: Progress and promise. Traditional Medicine Research, 10(8), 50. https://doi.org/10.53388/TMR20241005001
Liu, Q., Tian, J., Xu, Y., Li, C., Meng, X., & Fu, F. (2016). Protective effect of rosmarinic acid on myocardial infarction induced cardiac fibrosis via AT1R/p38 MAPK signaling and ACE2/ACE modulation. Journal of Agricultural and Food Chemistry, 64(35), 6716–6722. https://doi.org/10.1021/acs.jafc.6b03001
Libby, P., Buring, J. E., Badimon, L., Hansson, G. K., Deanfield, J., Bittencourt, M. S., Tokgözoğlu, L., & Lewis, E. F. (2019). Atherosclerosis. Nature Reviews Disease Primers, 5(1), 1–18. https://doi.org/10.1038/s41572-019-0106
Loussouarn, M., Krieger-Liszkay, A., Svilar, L., Bily, A., Birtić, S., & Havaux, M. (2017). Carnosic acid and carnosol, two major antioxidants of rosemary, act through different mechanisms. Plant Physiology, 175(3), 1381–1394. https://doi.org/10.1104/pp.17.01183
Manville, R. W., Baldwin, S. N., Eriksen, E. Ø., Jepps, T. A., & Abbott, G. W. (2023). Medicinal plant rosemary relaxes blood vessels by activating vascular smooth KCNQ channels. FASEB Journal, 37(9), e23125. https://doi.org/10.1096/fj.202301132R
Mirabal Rodríguez, J., Lazalde Ramos, B. P., Galván Valencia, M., & Quirarte Báez, S. M. (2025). Propiedades terapéuticas del romero (Rosmarinus officinalis L.) en el manejo de la diabetes mellitus 2: Perspectivas metabólicas y clínicas. Ciencia Latina Revista Científica Multidisciplinar, 9(3). https://doi.org/10.37811/cl_rcm.v9i1
Mu, W., Xu, G., Li, L., Wen, J., Xiu, Y., Zhao, J., Liu, T., Wei, Z., Luo, W., Yang, H., Wu, Z., Zhan, X., Xiao, X., & Bai, Z. (2025). Carnosic acid directly targets STING C terminal tail to improve STING mediated inflammatory diseases. Advanced Science, 12(14), e2417686. https://doi.org/10.1002/advs.202417686
Murino Rafacho, B. P., Portugal Dos Santos, P., Gonçalves, A. F., Fernandes, A. A. H., Okoshi, K., Chiuso-Minicucci, F., Azevedo, P. S., Mamede Zornoff, L. A., Minicucci, M. F., Wang, X. D., & Rupp de Paiva, S. A. (2017). Rosemary supplementation attenuates cardiac remodeling after myocardial infarction in rats. PLoS ONE, 12(5), e0177521. https://doi.org/10.1371/journal.pone.0177521
Neves, J. A., Neves, J. A., & Oliveira, R. de C. M. (2018). Pharmacological and biotechnological advances with Rosmarinus officinalis L.: Expert opinion on therapeutic patents. Expert Opinion on Therapeutic Patents, 28(5), 399–413. https://doi.org/10.1080/13543776.2018.1459570
Nguyen, H. N., Ahn, Y. J., Medina, E. A., & Asmis, R. (2018). Dietary 23 hydroxy ursolic acid protects against atherosclerosis and obesity by preventing monocyte priming and dysfunction induced by dyslipidemia. Atherosclerosis, 275, 333–341. https://doi.org/10.1016/j.atherosclerosis.2018.06.882
Nyandwi, J. B., Ko, Y. S., Jin, H., Yun, S. P., Park, S. W., & Kim, H. J. (2020). Rosmarinic acid inhibits oxLDL induced inflammasome activation under high glucose conditions via p38–FOXO1–TXNIP downregulation. Biochemical Pharmacology, 182, 114246. https://doi.org/10.1016/j.bcp.2020.114246
Nyandwi, J. B., Ko, Y. S., Jin, H., Yun, S. P., Park, S. W., & Kim, H. J. (2021). Rosmarinic acid enhances macrophage cholesterol efflux through ABCA1 and ABCG1 regulation. International Journal of Molecular Sciences, 22(16), 8791. https://doi.org/10.3390/ijms22168791
Organización Mundial de la Salud. (2023). Diabetes. Organización Mundial de la Salud. https://www.who.int/news-room/fact-sheets/detail/diabetes
Pan, Q., Liu, Y., Ma, W., & Kan, R. (2022). Cardioprotective effects and potential mechanisms of luteolin in myocardial ischemia–reperfusion injury: A systematic review and meta analysis of preclinical evidence. Frontiers in Cardiovascular Medicine, 9, 685998. https://doi.org/10.3389/fcvm.2022.685998
Patrignani, F., Prasad, S., Novakovic, M., Marin, P. D., & Bukvicki, D. (2021). Lamiaceae in the treatment of cardiovascular diseases. Frontiers in Bioscience, 26(4), 612–643. https://doi.org/10.2741/4909
Polegato, B. F., Minicucci, M. F., Azevedo, P. S., Gonçalves, A. F., Lima, A. F., Martinez, P. F., et al. (2016). Relationship between functional variables and heart failure after myocardial infarction in rats. Arquivos Brasileiros de Cardiologia, 106(2), 105–112. https://doi.org/10.5935/abc.20160015
Prasannarong, M., Saengsirisuwan, V., Surapongchai, J., Buniam, J., Chukijrungroat, N., & Rattanavichit, Y. (2019). Rosmarinic acid improves hypertension and skeletal muscle glucose transport in angiotensin II treated rats. BMC Complementary and Alternative Medicine, 19(1), 165. https://doi.org/10.1186/s12906-019-2579-4
Razavi-Azarkhiavi, K., Iranshahy, M., Sahebkar, A., Shirani, K., & Karimi, G. (2016). The protective role of phenolic compounds against doxorubicin induced cardiotoxicity: A comprehensive review. Nutrition and Cancer, 68(6), 892–917. https://doi.org/10.1080/01635581.2016.1187280
Sadzuka, Y., Sugiyama, T., Shimoi, K., Kinae, N., & Hirota, S. (1997). Protective effect of flavonoids on doxorubicin induced cardiotoxicity. Toxicology Letters, 92(1), 1–7. https://doi.org/10.1016/s0378-4274(97)00028-3
Sassi, A., Laouani, A., Nasrallah, H., Ben Abdessalem, M. A., Ferdousi, F., Nouira, M., Mtiraoui, A., Jarray, I., Mahdhaoui, A., Isoda, H., & Saguem, S. (2025). Effect of Rosmarinus officinalis infusion supplementation on blood pressure among healthy volunteers and grade 1 hypertensive patients. Phytomedicine Plus, 5, 100783. https://doi.org/10.1016/j.phyplu.2025.100783
Shang, W., Li, X. H., Zeng, L. H., Li, Z., Hu, Y., Wen, H. M., … Wan, G. X. (2025). Mechanistic perspectives on flavonoid subclasses as cardioprotective agents against doxorubicin induced cardiotoxicity: A comprehensive review. Drug Design, Development and Therapy, 19, 5553–5596. https://doi.org/10.2147/DDDT.S535517
Vahdati Hassani, F., Shirani, K., & Hosseinzadeh, H. (2016). Rosemary (Rosmarinus officinalis) as a potential therapeutic plant in metabolic syndrome: A review. Naunyn Schmiedeberg’s Archives of Pharmacology. https://doi.org/10.1007/s00210-016-1256-0
Verma, H., Bhattacharjee, A., Shivavedi, N., & Nayak, P. K. (2022). Rosmarinic acid attenuates myocardial injury by modulating AT1R/p38 MAPK and NF κB pathways in maternally separated rats. Naunyn Schmiedeberg’s Archives of Pharmacology, 395, 1189–1207. https://doi.org/10.1007/s00210-022-02282-1
Williams, B., Mancia, G., Spiering, W., Agabiti Rosei, E., Azizi, M., Burnier, M., Clement, D. L., Coca, A., de Simone, G., Dominiczak, A., Kahan, T., Mahfoud, F., Redon, J., Ruilope, L., Zanchetti, A., Kerins, M., Kjeldsen, S. E., Kreutz, R., Laurent, S., … ESC Scientific Document Group. (2018). 2018 ESC/ESH guidelines for the management of arterial hypertension. European Heart Journal, 39(33), 3021–3104. https://doi.org/10.1093/eurheartj/ehy339
World Health Organization. (2025, July 31). Cardiovascular diseases (CVDs). https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)
Wu, P., Meng, X., Zheng, H., Zeng, Q., Chen, T., Wang, W., & Zhang, X. (2021). Luteolin and its role in chronic diseases. Advances in Clinical and Experimental Medicine, 30(3), 307–315. https://doi.org/10.17219/acem/132507
Yang, J. T., Wang, J., Zhou, X. R., Li, X., Chen, Y., & Wan, G. X. (2018). Luteolin alleviates cardiac ischemia/reperfusion injury in hypercholesterolemic rats via activation of Akt/Nrf2 signaling. Naunyn Schmiedeberg’s Archives of Pharmacology, 391, 719–728. https://doi.org/10.1007/s00210-018-1496-2
Yousefian, M., Hosseinzadeh, H., Hayes, A. W., Hadizadeh, F., & Karimi, G. (2022). The protective effect of natural compounds on doxorubicin induced cardiotoxicity via nicotinamide adenine dinucleotide phosphate oxidase inhibition. The Journal of Pharmacy and Pharmacology, 74(3), 351–359. https://doi.org/10.1093/jpp/rgab109
Zavala Hope, L., Peralta Quiroz, S. Y., Narváez Calderón, J. M., & Patiño Zambrano, F. A. (2024). Cardiovascular disease mortality and its risk factors at the global level. Maginvestigar, 8(1). https://doi.org/10.5281/zenodo.10521558
Zhang, Q. L., Yang, J. J., & Zhang, H. S. (2019). Carvedilol combined with carnosic acid attenuates doxorubicin induced cardiotoxicity by suppressing oxidative stress, inflammation, apoptosis, and autophagy. Biomedicine & Pharmacotherapy, 109, 71–83. https://doi.org/10.1016/j.biopha.2018.07.037
Zhang, W., Li, D., Shan, Y., Tao, Y., Chen, Q., Hu, T., Gao, M., Chen, Z., Jiang, H., Du, C., Wang, M., & Guo, K. (2023). Luteolin intake is negatively associated with all cause and cardiac mortality among patients with type 2 diabetes mellitus. Frontiers in Nutrition, 10, 1123451. https://doi.org/10.3389/fnut.2023.1123451
Zhang, Y., Yu, J., Dong, X., & Zhang, L. (2020). Ursolic acid attenuates cardiac remodeling and dysfunction in pressure overloaded mice by regulating apoptosis, oxidative stress, and extracellular matrix remodeling. Journal of Cellular and Molecular Medicine, 24(3), 1959–1971. https://doi.org/10.1111/jcmm.14862
Zhao, M., Wang, J., & Xiang, M. (2021). Oxidative stress in heart failure: Molecular mechanisms and therapeutic strategies. Frontiers in Cardiovascular Medicine, 8, 750968. https://doi.org/10.3389/fcvm.2021.750968
Zych, M., Wojnar, W., Borymski, S., Szałabska, K., Bramora, P., & Kaczmarczyk Sedlak, I. (2019). Effect of rosmarinic acid and sinapic acid on oxidative stress parameters in the cardiac tissue and serum of type 2 diabetic female rats. Antioxidants, 8(12), 579. https://doi.org/10.3390/antiox8120579
Derechos de autor 2026 Sandy Fidel Roríguez Reyes , Blanca Patricia , Marisol Galván Valencia, María Concepción Guerrero Correa, Judisett Mirabal Rodríguez

Esta obra está bajo licencia internacional Creative Commons Reconocimiento 4.0.









.png)
















.png)
1.png)

