De la Contaminación al Desequilibrio Hormonal: El Caso del Río Atoyac y la Fertilidad Femenina

Palabras clave: río Atoyac, disruptores endocrinos, infertilidad, reproducción

Resumen

La cuenca del Río Atoyac, en México, constituye una zona crítica de contaminación ambiental debido al crecimiento industrial y urbano, así como a la deficiente gestión de residuos. En sus aguas y suelos se han identificado metales pesados, plaguicidas, compuestos orgánicos volátiles y microplásticos, a los cuales la población se expone cotidianamente por ingesta, inhalación y contacto dérmico. Muchos de estos compuestos actúan como disruptores endocrinos, con efectos adversos específicos sobre la salud reproductiva femenina. Esta revisión analiza la evidencia disponible sobre la asociación entre dichos contaminantes y alteraciones hormonales, endometriosis, síndrome de ovario poliquístico, falla ovárica prematura y fallos de implantación, así como complicaciones gestacionales. Los hallazgos resaltan la necesidad de estudios en las comunidades aledañas al río y de políticas públicas más estrictas de control y prevención.

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Adeogun, A. E., Ogunleye, O. D., Akhigbe, T. M., Oyedokun, P. A., Adegbola, C. A., Saka, W. A., Afolabi, O. A., & Akhigbe, R. E. (2024). Impact of arsenic on male and female reproductive function: a review of the pathophysiology and potential therapeutic strategies. Naunyn-Schmiedeberg S Archives Of Pharmacology. https://doi.org/10.1007/s00210-024-03452-6

Ahmad, M. F., Ahmad, F. A., Alsayegh, A. A., Zeyaullah, M., AlShahrani, A. M., Muzammil, K., Saati, A. A., Wahab, S., Elbendary, E. Y., Kambal, N., Abdelrahman, M. H., & Hussain, S. (2024). Pesticides impacts on human health and the environment with their mechanisms of action and possible countermeasures. Heliyon, 10(7), e29128. https://doi.org/10.1016/j.heliyon.2024.e29128

Ali, L., Alam, A., Ali, A. M., Teoh, W. Y., & Altarawneh, M. (2024). A comprehensive Review into Emission Sources, Formation Mechanisms, Ecological Effects, and Biotransformation Routes of Halogenated Polycyclic Aromatic Hydrocarbons (HPAHs). Ecotoxicology And Environmental Safety, 286, 117196. https://doi.org/10.1016/j.ecoenv.2024.117196

Ali, W., Buriro, R. S., Gandahi, J. A., Chen, Y., Aabdin, Z. U., Bhutto, S., Sun, J., Zhu, J., Liu, Z., & Zou, H. (2024). A critical review on male-female reproductive and developmental toxicity induced by micro-plastics and nano-plastics through different signaling pathways. Chemico-Biological Interactions, 394, 110976. https://doi.org/10.1016/j.cbi.2024.110976

Ashry, A., & Naggar, Y. A. (2025). Microplastic contamination in water, fish, and shrimp collected from the Nile River in Upper Egypt poses ecological and human health hazards. Environmental Research, 121945. https://doi.org/10.1016/j.envres.2025.121945

Collin, M. S., Venkatraman, S. K., Vijayakumar, N., Kanimozhi, V., Arbaaz, S. M., Stacey, R. G. S., Anusha, J., Choudhary, R., Lvov, V., Tovar, G. I., Senatov, F., Koppala, S., & Swamiappan, S. (2022). Bioaccumulation of lead (Pb) and its effects on human: A review. Journal Of Hazardous Materials Advances, 7, 100094. https://doi.org/10.1016/j.hazadv.2022.100094

Consejo Nacional de Humanidades, Ciencias y Tecnologías (CONAHCYT). (2023). 1er informe estratégico. Cuenca del Alto Atoyac (Tlaxcala y Puebla): Región de emergencia sanitaria y ambiental; problemática socioambiental y recomendaciones para su atención integral (Versión octubre de 2023). https://conahcyt.mx

Covarrubias-López, A. C., García-Suastegui, W. A., Valencia-Quintana, R., Avelino-Flores, F., Méndez-Bermúdez, A., & Handal-Silva, A. (2023). Human Impact in the Watershed of the Atoyac River in the Metropolitan Area of Puebla, Mexico. Sustainability, 15(13), 10565. https://doi.org/10.3390/su151310565

Ćwiertnia, A., Kozłowski, M., & Cymbaluk-Płoska, A. (2022). The Role of Iron and Cobalt in Gynecological Diseases. Cells, 12(1), 117. https://doi.org/10.3390/cells12010117

Du Plessis, M., Fourie, C., Stone, W., & Engelbrecht, A. (2023). The impact of endocrine disrupting compounds and carcinogens in wastewater: Implications for breast cancer. Biochimie, 209, 103-115. https://doi.org/10.1016/j.biochi.2023.02.006

Dueñas-Moreno, J., Vázquez-Tapia, I., Mora, A., Cervantes-Avilés, P., Mahlknecht, J., Capparelli, M. V., Kumar, M., & Wang, C. (2023). Occurrence, ecological and health risk assessment of phthalates in a polluted urban river used for agricultural land irrigation in central Mexico. Environmental Research, 240, 117454. https://doi.org/10.1016/j.envres.2023.117454

Edo, G. I., Itoje-Akpokiniovo, L. O., Obasohan, P., Ikpekoro, V. O., Samuel, P. O., Jikah, A. N., Nosu, L. C., Ekokotu, H. A., Ugbune, U., Oghroro, E. E. A., Emakpor, O. L., Ainyanbhor, I. E., Mohammed, W. A., Akpoghelie, P. O., Owheruo, J. O., & Agbo, J. J. (2024). Impact of environmental pollution from human activities on water, air quality and climate change. Deleted Journal. https://doi.org/10.1016/j.ecofro.2024.02.014

Estrada-Rivera, A., Fonseca, A. D., Mora, S. T., Suastegui, W. A. G., Bravo, E. C., Vega, R. C., Perales, J. L. M., & Handal-Silva, A. (2022). The Impact of Urbanization on Water Quality: Case Study on the Alto Atoyac Basin in Puebla, Mexico. Sustainability, 14(2), 667. https://doi.org/10.3390/su14020667

Fucic, A., Duca, R. C., Galea, K. S., Maric, T., Garcia, K., Bloom, M. S., Andersen, H. R., & Vena, J. E. (2021). Reproductive Health Risks Associated with Occupational and Environmental Exposure to Pesticides. International Journal Of Environmental Research And Public Health, 18(12), 6576. https://doi.org/10.3390/ijerph18126576

Giri, S., Lamichhane, G., Khadka, D., & Devkota, H. P. (2024). Microplastics contamination in food products: Occurrence, analytical techniques and potential impacts on human health. Current Research In Biotechnology, 7, 100190. https://doi.org/10.1016/j.crbiot.2024.100190

Gonzalez-Martin, R., Palomar, A., Perez-Deben, S., Salsano, S., Quiñonero, A., Caracena, L., Fernandez-Saavedra, R., Fernandez-Martinez, R., Conde-Vilda, E., Quejido, A. J., Giles, J., Vidal, C., Bellver, J., & Dominguez, F. (2024). Higher Concentrations of Essential Trace Elements in Women Undergoing IVF May Be Associated with Poor Reproductive Outcomes Following Single Euploid Embryo Transfer. Cells, 13(10), 839. https://doi.org/10.3390/cells13100839

Hassan, S., Thacharodi, A., Priya, A., Meenatchi, R., Hegde, T. A., R, T., Nguyen, H., & Pugazhendhi, A. (2023). Endocrine disruptors: Unravelling the link between chemical exposure and Women’s reproductive health. Environmental Research, 241, 117385. https://doi.org/10.1016/j.envres.2023.117385

Hernandez-Ramirez, A., Martinez-Tavera, E., Rodriguez-Espinosa, P., Mendoza-Pérez, J., Tabla-Hernandez, J., Escobedo-Urías, D., Jonathan, M., y Sujitha, S. (2019). Detección, procedencia y riesgos ambientales asociados de contaminantes de la calidad del agua durante eventos anómalos en el río Atoyac, centro de México: Un enfoque de monitoreo en tiempo real. The Science Of The Total Environment , 669 , 1019-1032. https://doi.org/10.1016/j.scitotenv.2019.03.138

Javan, K., Darestani, M., Ibrar, I., & Pignatta, G. (2025). Interrelated Issues within the Water-Energy-Food Nexus with a Focus on Environmental Pollution for Sustainable Development: A Review. Environmental Pollution, 368, 125706. https://doi.org/10.1016/j.envpol.2025.125706

Kumar, S., Sharma, A., & Kshetrimayum, C. (2019). Environmental & occupational exposure & female reproductive dysfunction. The Indian Journal Of Medical Research, 150(6), 532. https://doi.org/10.4103/ijmr.ijmr_1652_17

Land, K. L., Ghuneim, S. M., Williams, B. A., & Hannon, P. R. (2025). Phthalates Disrupt Female Reproductive Health: A Call for Enhanced Investigation into Mixtures. Reproduction. https://doi.org/10.1530/rep-24-0117

Laws, M. J., Neff, A. M., Brehm, E., Warner, G. R., & Flaws, J. A. (2021). Endocrine disrupting chemicals and reproductive disorders in women, men, and animal models. Advances In Pharmacology, 151-190. https://doi.org/10.1016/bs.apha.2021.03.008

Liu, Z., Zhuan, Q., Zhang, L., Meng, L., Fu, X., & Hou, Y. (2021). Polystyrene microplastics induced female reproductive toxicity in mice. Journal Of Hazardous Materials, 424, 127629. https://doi.org/10.1016/j.jhazmat.2021.127629

López-Velázquez, K., Ronderos-Lara, J. G., Saldarriaga-Noreña, H. A., Murillo-Tovar, M. A., Villanueva-Rodríguez, M., Guzmán-Mar, J. L., Hoil-Canul, E. R., & Cabellos-Quiroz, J. L. (2024). Endocrine-disrupting compounds in urban rivers of the southern border of Mexico: Occurrence and ecological risk assessment. Emerging Contaminants, 11(1), 100456. https://doi.org/10.1016/j.emcon.2024.100456

Maksymowicz, M., Ręka, G., Machowiec, P., & Piecewicz-Szczęsna, H. (2022). Impact of Triclosan on Female and Male Reproductive System and Its Consequences on Fertility; A Literature Review. Journal Of Family & Reproductive Health. https://doi.org/10.18502/jfrh.v16i1.8592

Manisalidis, I., Stavropoulou, E., Stavropoulos, A., & Bezirtzoglou, E. (2020). Environmental and Health Impacts of Air Pollution: A Review. Frontiers In Public Health, 8. https://doi.org/10.3389/fpubh.2020.00014

Marques, A. C., Mariana, M., & Cairrao, E. (2022). Triclosan and Its Consequences on the Reproductive, Cardiovascular and Thyroid Levels. International Journal Of Molecular Sciences, 23(19), 11427. https://doi.org/10.3390/ijms231911427

Meng, F., Liu, D., Bu, T., Zhang, M., Peng, J., & Ma, J. (2025). Assessment of pollution and health risks from exposure to heavy metals in soil, wheat grains, drinking water, and atmospheric particulate matter. Journal Of Environmental Management, 376, 124448. https://doi.org/10.1016/j.jenvman.2025.124448

Montano, L., Baldini, G. M., Piscopo, M., Liguori, G., Lombardi, R., Ricciardi, M., Esposito, G., Pinto, G., Fontanarosa, C., Spinelli, M., Palmieri, I., Sofia, D., Brogna, C., Carati, C., Esposito, M., Gallo, P., Amoresano, A., & Motta, O. (2025). Polycyclic Aromatic Hydrocarbons (PAHs) in the Environment: Occupational Exposure, Health Risks and Fertility Implications. Toxics, 13(3), 151. https://doi.org/10.3390/toxics13030151

Montano, L., Pironti, C., Pinto, G., Ricciardi, M., Buono, A., Brogna, C., Venier, M., Piscopo, M., Amoresano, A., & Motta, O. (2022). Polychlorinated Biphenyls (PCBs) in the Environment: Occupational and Exposure Events, Effects on Human Health and Fertility. Toxics, 10(7), 365. https://doi.org/10.3390/toxics10070365

Montero, A. A., Carnerero, C. S., Vidal, P. I., & Verdugo, A. A. (2016). Antiinflamatorios no esteroideos e infertilidad. Medicina de Familia SEMERGEN, 43(1), 72-73. https://doi.org/10.1016/j.semerg.2016.01.013

Mora, A., García-Gamboa, M., Sánchez-Luna, M. S., Gloria-García, L., Cervantes-Avilés, P., & Mahlknecht, J. (2021). A review of the current environmental status and human health implications of one of the most polluted rivers of Mexico: The Atoyac River, Puebla. The Science Of The Total Environment, 782, 146788. https://doi.org/10.1016/j.scitotenv.2021.146788

Panagopoulos, P., Mavrogianni, D., Christodoulaki, C., Drakaki, E., Chrelias, G., Panagiotopoulos, D., Potiris, A., Drakakis, P., & Stavros, S. (2023). Effects of endocrine disrupting compounds on female fertility. Best Practice & Research Clinical Obstetrics & Gynaecology, 88, 102347. https://doi.org/10.1016/j.bpobgyn.2023.102347

Pérez-Debén, S., Gonzalez-Martin, R., Palomar, A., Quiñonero, A., Salsano, S., & Dominguez, F. (2020). Copper and lead exposures disturb reproductive features of primary endometrial stromal and epithelial cells. Reproductive Toxicology, 93, 106-117. https://doi.org/10.1016/j.reprotox.2020.01.008

Rani, L., Thapa, K., Kanojia, N., Sharma, N., Singh, S., Grewal, A. S., Srivastav, A. L., & Kaushal, J. (2020). An extensive review on the consequences of chemical pesticides on human health and environment. Journal Of Cleaner Production, 283, 124657. https://doi.org/10.1016/j.jclepro.2020.124657

Rao, J. N., & Parsai, T. (2025). Pollution and toxicity of heavy metals in wildfires-affected soil and surface water: A review and meta-analysis. Environmental Pollution, 125845. https://doi.org/10.1016/j.envpol.2025.125845

Rodriguez-Espinosa, P., Fonseca-Campos, J., Ochoa-Guerrero, K., Hernandez-Ramirez, A., Tabla-Hernandez, J., Martínez-Tavera, E., Lopez-Martínez, E., & Jonathan, M. (2023). Identifying pollution dynamics using discrete Fourier transform: From an urban-rural river, Central Mexico. Journal Of Environmental Management, 344, 118173. https://doi.org/10.1016/j.jenvman.2023.118173

Rojas, E., & Rojas, F. (2005). Modeling hysteresis of the soil-water characteristic curve. Soils and foundations, 45(3), 135-145. https://doi.org/10.3208/sandf.45.3_135

Rojas, E., Arroyo, H., Horta, J., de la Luz Pérez-Rea, M., López-Lara, T., & Hernández, J. B. (2020). Modeling the soil–water retention curves while the soil is deforming. Comptes Rendus. Mécanique, 348(12), 983-1001. https://doi.org/10.5802/crmeca.63

Serra, L., Estienne, A., Vasseur, C., Froment, P., & Dupont, J. (2021). Review: Mechanisms of Glyphosate and Glyphosate-Based Herbicides Action in Female and Male Fertility in Humans and Animal Models. Cells, 10(11), 3079. https://doi.org/10.3390/cells10113079

Shekhar, C., Khosya, R., Thakur, K., Mahajan, D., Kumar, R., Kumar, S., & Sharma, A. K. (2024). A Systematic Review of Pesticide Exposure, Associated Risks, and Long-Term Human Health Impacts. Toxicology Reports, 13, 101840. https://doi.org/10.1016/j.toxrep.2024.101840

Shruti, V., Jonathan, M., Rodriguez-Espinosa, P., & Rodríguez-González, F. (2018). Microplastics in freshwater sediments of Atoyac River basin, Puebla City, Mexico. The Science Of The Total Environment, 654, 154-163. https://doi.org/10.1016/j.scitotenv.2018.11.054

Szczęsna, D., Wieczorek, K., & Jurewicz, J. (2022). An exposure to endocrine active persistent pollutants and endometriosis — a review of current epidemiological studies. Environmental Science And Pollution Research, 30(6), 13974-13993. https://doi.org/10.1007/s11356-022-24785-w

Wang, L., Ma, X., & Liu, J. (2025). Adverse Effects of Pesticides on the Ovary: Evidence from Epidemiological and Toxicological Studies. Environment & Health. https://doi.org/10.1021/envhealth.4c00243

Ward, G., Watts, M. P. C., & Hansson, S. R. (2025). The unintended consequences of modernity: Pollution and its effect on reproductive, maternal and fetal health. Pregnancy Hypertension, 40, 101204. https://doi.org/10.1016/j.preghy.2025.101204

Williams, A. L., Bates, C. A., Pace, N. D., Leonhard, M. J., Chang, E. T., & DeSesso, J. M. (2018). Impact of chloroform exposures on reproductive and developmental outcomes: A systematic review of the scientific literature. Birth Defects Research, 110(17), 1267-1313. https://doi.org/10.1002/bdr2.1382

Yang, Q., Zhang, J., & Fan, Z. (2024). Association between volatile organic compounds exposure and infertility risk among American women aged 18–45 years from NHANES 2013–2020. Scientific Reports, 14(1). https://doi.org/10.1038/s41598-024-80277-6

Zhang, J., Su, T., Fan, Y., Cheng, C., Xu, L., & LiTian, N. (2023). Spotlight on iron overload and ferroptosis: Research progress in female infertility. Life Sciences, 340, 122370. https://doi.org/10.1016/j.lfs.2023.122370

Zuri, G., Karanasiou, A., & Lacorte, S. (2023). Microplastics: Human exposure assessment through air, water, and food. Environment International, 179, 108150. https://doi.org/10.1016/j.envint.2023.108150

Publicado
2026-05-16
Cómo citar
Cotzomi Castro, K. M., Rosas Licona, P. M., Badillo Morales, A. G., Cerna Cortez, J. R., & Alatriste , V. (2026). De la Contaminación al Desequilibrio Hormonal: El Caso del Río Atoyac y la Fertilidad Femenina. Ciencia Latina Revista Científica Multidisciplinar, 10(2), 7956-7977. https://doi.org/10.37811/cl_rcm.v10i2.23794
Sección
Ciencias de la Salud