Efecto de los inhibidores selectivos de la recaptación de serotonina en los linfocitos de pacientes con depresión
Resumen
La depresión es el trastorno mental más frecuente a nivel mundial cuya patología es compleja por los factores psicológicos y fisiopatológicos que conlleva. El tratamiento farmacológico es fundamental, no obstante, presenta altos porcentajes de resistencia ante lo cual varias investigaciones han identificado que las alteraciones del sistema inmune juegan un papel decisivo. Es por ello que el objetivo de este artículo es revisar la bibliografía actual sobre los efectos de los inhibidores selectivos de la recaptación de serotonina (ISRS), primera línea de manejo farmacológico, sobre las alteraciones del sistema inmune en pacientes con depresión. Es evidente la alteración de los linfocitos y citoquinas en la fisiopatología de la depresión y frente a los ISRS. Sin embargo, se requieren amplias investigaciones para establecer los patrones inmunes normales y su afectación frente a estos factores. Esto permitirá generar nuevas metas farmacológicas que disminuyan la resistencia, cronicidad y recurrencia de la depresión.
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Derechos de autor 2023 Alison Doménica Castillo Reyes ;Carolina Monserrath Aucanshala Pilatuña ;Joseph Alexander Cáceres Llerena ;Jessica Priscila Ayala Baño ;Solange Aracely Bonilla Fernández ;José David Campos Villegas ;Scarleth Nayeli Castillo Trujillo ;María de los Ángeles Aguilar Ochoa
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