Leiomioma Pulmonar Benigno Metastatizante, una Causa Infrecuente de Nódulos Pulmonares: Reporte de Caso y Revisión de Literatura
Resumen
El leiomioma uterino es el tumor ginecológico benigno más común, sin embargo, en raras ocasiones presenta un patrón de crecimiento extrauterino siendo la metástasis pulmonar lo más frecuente, denominándose leiomioma pulmonar benigno metastatizante (LBM). Se manifiesta como una entidad asintomática en la mayoría de los casos, asociada a nódulos pulmonares bilaterales dispersos no calcificados; el diagnóstico de certeza se realiza mediante histopatología e inmunohistoquímica, dada la rareza de la enfermedad el tratamiento aún no se encuentra completamente establecido. Teniendo entre sus opciones la resección quirúrgica, terapia hormonal y manejo expectante. Presentamos el caso de una paciente de 47 años de edad con antecedente de histerectomía secundaria a leiomiomatosis uterina 22 años previos a su valoración médica, la cual acudió por presentar disnea y tos crónica asociada a múltiples nódulos pulmonares realizándose el diagnóstico de leiomiomatosis pulmonar benigna metastatizante y que recibió tratamiento expectante, manteniéndose estable tras 3 años de seguimiento.
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Abramson S, G. R. (2001). Benign metastasizing leiomyoma: Clinical, imaging, and pathologic correlation. AJR Am J Roentgenol, 1409-1413.
Abu Saadeh F, R. C. (2018). Lung metastases from benign uterine leiomyoma: does 18-FDG-PET/CT have a role to play?. Irish Journal of Medical Science., 1-6.
Adair L.B. (2020). CT findings of pathology proven benign metastasizing leiomyoma. Radiology Case Reports., 2120-2124.
André D, G. F. (2021). Benign metastasizing leiomyoma - a case of benign metastasis. Journal of the Royal Society of Medicine Open., 1-3.
Aoki K, Y. T. (2020). Benign metastasizing leiomyoma in femur and thigh with a history of uterine leiomyoma: A case report and literature review. A case report and literature review., 1-3.
Bakkensen J.B, S. W. (2018). Pelvic and pulmonary benign metastasizing leiomyioma: A case report. Case Reports in Women´s Health, 1-6.
Barber E, E. A. (2019). enign Metastasizing Leiomyoma to the Lung and Spine: A Case Report and Literature Review. . Case Reports in Oncology., 218-223.
Boavida Ferreira J, C. R. (2022). Benign Metastasizing Leiomyomatosis to the Skin and Lungs, Intravenous Leiomyomatosis, and Leiomyomatosis Peritonealis Disseminata: a Series of five cases. The Oncologist., 89-98.
Brincat M.R, S. L. (2023). Pulmonary benign metastasizing uterine leiomyoma (PBML): a case report and review of the literature. Annals of Medicine & Surgery., 3686–3691.
Chen S, L. R. (2014). Pulmonary benign metastasizing leiomyoma: a case report and literature review. Journal of Thoracic Disease, 92-98.
Conde M, C. A. (2023). Benign metastasizing leiomyoma presenting as multiple pulmonary nodules: A radiological-pathological correlation. Pulmonology, 160-162.
Efared B, A. E. (2017). Unexpected pulmonary tumor: metastasis from a benign uterine leiomyoma in a post-menopausal woman: a case report. BMC Research Notes., 662-668.
Fan D, Y. X. (2014). Pulmonary benign metastasizing leiomyoma: a case report. Int J Clin Exp Pathol, 7072-7075.
Fan R, F. F. (2020). Pulmonary benign metastasizing leiomyomas: a case series of 23 patients at a single facility. BMC Pulmonary Medicine, 1-7.
Funakoshi Y, S. N. (2004). Pulmonary Benign Metastasizing Leiomyoma from the uterus in a Postmenopausal Woman: Report of a Case. Surgery Today, 55-57.
Gad M.M, G. M. (2020). Suspicious Right Heart Mass. A Rare Case of Benign Metastasizing Leiomyoma of the Tricuspid Valve. JACC Case Reports., 51-54.
Hai Yun D, S. L. (2020). Pulmonary benign metastasizing leiomyoma: A case report and review of the literature. World J Clin Cases, 3082-3089.
Hann M, M. R. (2017). Recurrent Pneumothoraces in a Patient With Pulmonary Benign Metastasizing Leiomyoma. Ochsner Journal., 284-287.
Jiang H, M. L. (2021). Pulmonary benign metastasizing leiomyoma: a case report and literature review. Annals of Palliative Medicine, 5831-5838.
Jo H.C, B. J. (2018). Case of pulmonary benign metastasizing leiomyoma from synchronous uterine leiomyoma in a postmenopausal woman. Gynecologic Oncology Reports, 33-36.
Khan M, F. A. (2018). Pulmonary benign metastasizing leiomyoma: A case report. Respiratory Medicine Case Reports., 117-121.
Kim Y.N, E. K. (2018). Aberrant uterine leiomyomas with extrauterine manifestation: intravenous leiomyomatosis and benign metastasizing leiomyomas. Obstetrics & Gynecology Science., 509-519.
Kyriakopoulos K, D. E. (2018). Recurrent benign leiomyomas after total abdominal hysterectomy. Rich or poor estrogenic environment may lead to their recurrence?. International Journal of Surgery Case Reports., 191–193.
Le Guen P, P. N. (2021). Spontaneous Regression of miliary Pattern after Delivery. Benign Pulmonary Metastasizing Leiomyoma. American Journal of Respiratory and Critical Care Medicine., 906-907.
Lee S.R, C. Y. (2017). Multiple cavitating pulmonary nodules; Rare manifestasion of benign metastatic leiomyoma. Journal of Thoracic Disease, 1-5.
Li Q, W. Y. (2019). A case of pulmonary benign metastasizing leiomyoma: clinicopathologic, inmunohistochemical, and PET/CT analyses. Transltional Cancer Research., 2496-2503.
Matos F, S. C. (2019). Multisystemic Benign Metastasizing Leiomyoma: An Unusual Condition with an Atypical Clinical Presentation. Case Reports in Radiology., 1-4.
Mauduit M, L. Q. (2018). Post-menopausal pulmonary leiomyoma metastasis: an unexpected finding. Indian Journal of Thoracic and Cardiovascular Surgery., 513-515.
Medarov B.I, K. M. (2018). Multiple Lung Masses in a Young Woman. JAMA, 2141- 2142.
Meddeb M, C. R. (2018). The Heart as a Site of Metastasis of Benign Metastasizing Leiomyoma: Case Report and Review of the Literature. Case Reports in Cardiology., 1-5.
Nguyen T, D. P. (2017). Cancer gene mutations in benign metastasizing leiomyoma: a case report. Cureus, 1-8.
Ofori K, F. H. (2019). Benign metastasizing leiomyoma presenting with miliary pattern and fatal outcome: Case report with molecular analysis & review of the literature. Respiratory Medicine Case Reports., 1-6.
Palafox D, P. J. (2012). Leiomiomatosis benigna pulmonar metastatizante. Revista de patología respiratoria., 85-88.
Padhi P, T. M. (2021). Benign Metastasizing Leiomyoma of the Uterus with Pulmonary and Bone Metastases. Case Reports in Obstetrics and Gynecology., 1-5.
Parker N.A, D. C., & D., L. (2018). Metastasis of Benign Leiomyomas Outside the Uterus. Kansas Journal of Medicine., 56–58.
Raposo M.I, M. C. (2018). Benign Metastasizing Leiomyoma of the Uterus: Rare Manifestation of a Frequent Pathology. Case Reports in Obstetrics and Gynecology., 1-8.
Su H, F. R. (2023). Pulmonary benign metastasizing leiomyoma in patients aged 45 years and younger: clinical features and novelty in treatment. BMC Pulmonary Medicine, 1-9.
Tang E.K, W. F. (2019). Benign Metastasising Leiomyomatosis of the Lung Presenting as Progressive Pneumothorax. Heart Lung Circ., 94-95.
Tong T, F. Q. (2023). Benign metastasizing uterine leiomyoma with lymphatic and pulmonary metastases: a case report and literature review. BMC Women’s Health, 1-7.
Wojtys M.E, J. O. (2022). Benign metastasizing leiomyoma of the lung: Diagnostic process and treatment based on three case reports and a review of the literature. Biomedicines, 1-13.
Y Fu, H. L. (2012). Pulmonary benign metastasizing leiomyoma: a case report and review of the literature. World Journal of Surgical Oncology., 1-4.
Yoon G, K. T. (2011). Benign Metastasizing Leiomyoma with Multiple Lymph Node Metastasis: A Case Report. Cancer Research and Treatment., 131-133.
Yuan X, S. Y. (2019). Multiple organ benign metastasizing leiomyioma: A case report and literature review. Journal of Obstetrics and Gynecology Research, 1-5.
Zazulak H.E, S. M. (2023). Incidental detection of benign metastasizing leiomyoma in asyntomatic female. Journal of Clinical Imaging Science., 1-4.
Zhang J, D. A. (2019). Diffuse cavitary benign metastasising leiomyoma of the lung. Thorax., 208-209.
Zong D, H. W. (2018). Concurrent benign metastasizing leiomyoma in the lung and lumbar spine with elevated standardized uptake value level in positron-emission tomography computed tomography. Medicine, 1-6.
Derechos de autor 2023 Rodolfo Martín Ruiz Ravelo , Alma Iris Cano Rodríguez, Perla Karina Hernández De Lira, Elizabeth Torres Ruiz
Esta obra está bajo licencia internacional Creative Commons Reconocimiento 4.0.