Estado Funcional de los Adultos Mayores Sobrevivientes a Covid19 Grave Afiliados a la Umf 9
Resumen
Poco se conoce el impacto de la pandemia por COVID19, ya que se ha priorizado el disponer de vacunas y fármacos que ayuden a combatir esta enfermedad. Desconocemos la situación funcional de los sobrevivientes a COVID19 grave. Objetivo: Determinar el estado funcional de las personas mayores de 65 años de la Unidad de medicina familiar N9 que cursaron con COVID19 grave. Metodología: Se realizó un estudio transversal descriptivo, de mayo 2023 a junio del 2023. Se registró información que incluyó edad, género, mes y año en que padeció covid19, días de oxígeno suplementario. Se aplicó el índice de Lawton y Brody por entrevista a los adultos mayores de 65 años de edad o al cuidador primario. Resultados: La muestra fue de 95 pacientes. La mitad de los pacientes no estan alfabetizados y una alta proporción vive con sus hijos. El 6% cuenta con empleo temporal. Los casos se dieron en el 2020 y 2021. Solo la edad mostró asociación con menor puntuación en la escala de Lawton y Brody. La posibilidad de ser dependiente en menores de 80 años se estimó OR 0.17 (IC95% 0.06-0.46) p < 0.001. Conclusión: El estado funcional predominante es de dependencia moderada. Los adultos menores de 80 años tienen menor posibilidad de tener puntaje bajo en la escala de Lawton y Brody.
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Jin Y, Ji W, Yang H, et al. Endothelial activation and dysfunction in Covid-19: From basic mechanisms to potential therapeutic approaches, Signal Transduct Target Ther. 2020; ;5(1):1–13
Liu P, Blet A, Smyth D, et al. The science underlying Covid-19: Implications for the cardiovascular system, Circulation 2020;142(1):68–78.
Hamming I, Cooper M, Haagmans B, et al. The emerging role of ace2 in physiology and disease. JPathol. 2007; 212(1):1–11.
Giustino G, Pinney S, Lala A, et al. Coronavirus and cardiovascular disease, myocardial injury, and arrhythmia, J Am Coll Cardiol, 2020; 76(17):2011–2023
Gheblawi M, Wang K, Viveiros A, et al. Angiotensin- converting enzyme 2: Sars-cov-2 receptor and regulator of the renin-angiotensin system: Celebrating the 20th anniversary of the discovery of ace2. Circ Res. 2020;126(10):1456–74.
Zachariah U, Nair S, Goel A, et al. Targeting raised von willebrand factor levels and macrophage activation in severe Covid-19: Consider low volume plasma exchange and low dose steroid, Thromb Res. 2020; 192:2.
Escher, R, Breakey N, Lammle B. Severe Covid-19 infection associated with endothelial activation. Thromb Res. 2020; 190:62.
Varga Z, Flammer, A, Steiger P, et al. Endothelial cell infection and endothelitis in Covid-19. Lancet. 2020; 395(10234):1417–1418.
Canas C. The triggering of post-Covid-19 autoimmunity phenomena could be associated with both transient immunosuppression and an inappropriate form of immune reconstitution in susceptible individuals, Med Hypotheses. 2020; 145(110345):110345.
Loarce J, Garcia A, López F, et al. High rates of severe disease and death due to sars- cov-2 infection in rheumatic disease patients treated with rituximab: A descriptive study. Rheumatol. Int. 2020; 40(12):2015–2021
Dhanalakshmi K, Venkataraman, A, Balasubramanian, et al. Epidemiological and clinical profile of pediatric inflammatory multisystem syndrome. Temporally associated with sars-cov-2 in indian children. Indian Pediatr. 2020; 57(11):1010–1014.
Sedaghat Z, Karimi N. Guillain barre syndrome associated with Covid-19 infection: A case report. J. Clin. Neurosci. 2020; 76:233–235.
Ferri C, Giuggioli D, Raimondo V, et al. Covid-19 and rheumatic autoimmune systemic diseases: Report of a large italian patients series. Clin. Rheumatol. 2020; 39(11):3195–3204.
Veenstra J, Buechler C, Robinson G, et al. Antecedent immunosuppressive therapy for immune-mediated inflammatory diseases in the setting of a Covid-19 outbreak. J. Am. Acad. Dermatol. 2020; 83(6):1696–1703.
Pablos J, Galindo M, Carmona L, et al. Clinical outcomes of hospitalised patients with Covid-19 and chronic inflammatory and autoimmune rheumatic diseases: A multicentric matched cohort study. Ann Rheum Dis. 2020; 79(12): 1544-1549.
AlKhawaga S, Abdelalim E. Potential application of mesenchymal stem cells and their exosomes in lung injury: An emerging therapeutic option for Covid-19 patients. Stem Cell Res. Ther. 2020; 11(1).
Sidarta D, Jara C, Ferruzzi A.J, et al. Sars-cov-2 receptor is co-expressed with elements of the kinin-kallikrein, renin-angiotensin and coagulation systems in alveolar cells. Sci. Rep. 2020; 10(1):1-19.
Ackermann M, Verleden S, Kuehnel M, et al. Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19. N. Engl. J. Med. 2020; 383(2):120–128.
Fuji H, Tsuji T, Yuba T, et al. High levels of anti-ssa/ro antibodies in Covid-19 patients with severe respiratory failure: A case-based review: High levels of anti-ssa/ro antibodies in Covid-19. Clin. Rheumatol. 2020; 39(11):3171-3175.
Richardson S, Hirsch J, Narasimhan M, et al. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with Covid-19 in the new york city area. JAMA 2020; 323(20):2052.
Najafi S, Rajaei E, Moallemian R, et al. The potential similarities of Covid-19 and autoimmune disease pathogenesis and therapeutic options: New insights approach. Clin. Rheumatol. 2020; 39(11):3223-3235.
Khan M, Khan H, Nawaz M, et al. Epidemiological and clinical characteristics of coronavirus disease (Covid-19) cases at a screening clinic during the early outbreak period: A single-centre study. J Med Microbiol. 2020; 69(8):1114-1123.
Cobos M, Cubero P, Arroyo I, et al. Cause-specific death in hospitalized individuals infected with sars-cov-2: More than just acute respiratory failure or thromboembolic events. Intern. Emerg. Med. 2020; 15(8):1533-1544.
Rajai A, Patel R, Gerova N, et al. Pulmonary thromboembolic disease in Covid-19 patients on ct pulmonary angiography-Prevalence, pattern of disease andrelationship to d-dimer. Eur J Radiol. 2020; 132(109336):109336
Uppuluri E, Shapiro N. Development of pulmonary embolism in a nonhospitalized patient with Covid-19 who did not receive venous thromboembolism prophylaxis. Am J Health Syst Pharm. 2020; 77(23):1957-1960.
Pisano T, Joki J, Hon B, et al. Pulmonary embolism after acute spinal cord injury and Covid-19. Am. J. Phys. Med. Rehabil. 2020; 99(11):982-985.
Sakr Y, Giovini M, Leone M, et al. Pulmonary embolism in patients with coronavirus disease-2019 (Covid-19) pneumonia: A narrative review. Ann. Intensive Care 2020; 10(1).
Ackermann M, Verleden S, Kuehnel M, et al. Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19. N. Engl. J. Med. 2020; 383(2):120-128.
Van Kruijsdijk R, De Jong P, Abrahams A. Pulmonary vein thrombosis in Covid-19. BMJ Case Rep. 2020; 13(10):e239986.
Korkmaz B, Lesner A, Marchand-Adam S, et al. Lung protection by cathepsin c inhibition: A new hope for Covid-19 and ards? J. Med. Chem. 2020; 63(22):13258-13265.
Zhou P, Yang X, Wang X, et al. Addendum: A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 2020; 579(7798):270-3.
Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study. Lancet 2020; 395(10229):1054-62.
Li F, Li W, Farzan M, et al. Structure of SARS coronavirus spike receptor-binding domain complexed with receptor. Science 2005; 309(5742):1864-1868.
Wang D, Hu B, Zhu F, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA 2020; 323(11):1061.
Shi S, Qin M, Shen B, et al. Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China. JAMA Cardiol. 2020; 5(7):802.
Qin C, Zhou L, Hu Z, et al. Dysregulation of immune response in patients with coronavirus 2019 (Covid-19) in Wuhan, China. Clin. Infect. Dis. 2020; 71(15):762-768.
Hobai I, Edgecomb J, LaBarge K, et al. Dysregulation of intracellular calcium transporters in animal models of sepsis-induced cardiomyopathy. Shock 2015; 43(1):3-15.
Booth C, Matukas L, Tomlinson G, et al. Clinical features and short-term outcomes of 144 patients with Sars in the greater Toronto area. JAMA 2003; 289(21):2801.
Pant P, Joshi A, Basnet B, et al. Prevalence of Functional Limitation in COVID-19 Recovered Patients Using the Post COVID-19 Functional Status Scale. JNMA J Nepal Med Assoc. 2021 Jan 31;59(233):7-11.
Haberman R, Castillo R, Chen A, et al. Covid-19 in patients with inflammatory arthritis: A prospective study on the effects of comorbidities and disease-modifying antirheumatic drugs on clinical outcomes. Arthritis Rheumatol. 2020; 72(12):1981-1989.
Hassen L, Almaghlouth I, Hassen I, et al. Impact of Covid-19 outbreak on rheumatic patients’ perceptions and behaviors: A cross-sectional study. Int. J. Rheum. Dis. 2020; 23(11):1541-1549.
Goncalves L, Gonzales A, Patatt F, et al. Kawasaki and Covid-19 disease in children: A systematic review. Rev. Assoc. Med. Bras. 2020; 66(suppl 2):136-42.
Giustino G, Croft L, Oates C, et al. Takotsubo Cardiomyopathy in COVID-19. J Am Coll. Cardiol. 2020; 76(5):628–9.
Shah R, Shah M, Li A, et al. Takotsubo Syndrome and COVID-19: Associations and Implications. Curr. Probl. Cardiol. 2021; 46(3):100763.
Taboada M, Cariñena A, Moreno E, et al. Post-COVID-19 functional status six-months after hospitalization. J Infect. 2021; 82(4):e31-e33.
Hambrecht R, Wolf A, Gielen S, et al. Effect of exercise on coronary endothelial function in patients with coronary artery disease. N. Engl. J. Med. 2000; 342(7): 454-460.
Klok FA, Boon GJAM, Barco S, et al. The Post-COVID-19 Functional Status scale: a tool to measure functional status over time after COVID-19. Eur Respir J. 2020 Jul 2;56(1):2001494.
Ye Q, Wang B, Zhang T, et al. The mechanism and treatment of gastrointestinal symptoms in patients with Covid-19. Am. J. Physiol Gastrointest Liver Physiol 2020; 319(2):G245-52.
Trottein F, Sokol H. Potential causes and consequences of gastrointestinal disorders during a sars-cov-2 infection. CellRep.2020; 32(3):107915.
Dong Z, Xiang B, Jiang M, et al. The prevalence of gastrointestinal symptoms, abnormal liver function, digestive system disease and liver disease in Covid-19 infection: A systematic review and meta-analysis. J Clin Gastroenterol. 2021; 55 (1):67-76.
Bilal M, Sawhney M, Feuerstein J. Coronavirus disease 2019: Implications for the gastroenterologist. Curr Opin Gastroenterol. 2021; 37(1):23-9.
Chen R, Yu Y, Li W, et al. Gastrointestinal symptoms associated with un favorable prognosis of Covid-19 patients: A retrospective study. Front Med. 2020; 7.
Zhang L, Pang R, Qiao Q, et al. Successful recovery of Covid-19-associated recurrent diarrhea and gastrointestinal hemorrhage using convalescent plasma. Mil Med Res 2020; 44-45.
Martin T, Wan D, Hajifathalian K, et al. Gastrointestinal bleeding in patients with coronavirus disease 2019: A matched case-control study. Am. J. Gastroenterol. 2020; 115(10):1609-16.
Bernard A, Serna-Higuita L, Martus P, et al. COVID-19 does not influence functional status after ARDS therapy. Crit Care. 2023 5;27(1):48.
Abdelmohsen M, Alkandari B, Gupta V, et al. Diagnostic value of abdominal sonography in confirmed Covid-19 intensive care patients. Egypt. J. Radiol. Nucl. Med. 2020; 51(1).
Singh A, Bhushan B, Maurya A, et al. Coronavirus disease 2019 (Covid-19) and neurodegenerative disorders. Dermatol Ther 2020; 33(4).
Nigro E, Polito R, Alfieri A, et al. Molecular mechanisms involved in the positive effects of physical activity on coping with Covid-19. Eur. J. Appl. Physiol. 2020; 120(12):2569–82
Li Y, Bai W, Hashikawa T. The neuroinvasive potential of sars cov2 may play a role in the respiratory failure of Covid-19 patients. J. Med. Virol. 2020; 92(6):552-5.
Sanghvi A. Covid19: An overview for dermatologists. Int J. Dermatol. 2020; 59 (12):1437-1449.
ZahediNiaki O, Anadkat M, Chen S, et al. Navigating immunosuppression in a pandemic: A guide for the dermatologist from the covid task force of the medical dermatology society and society of dermatology hospitalists. J Am Acad Dermatol. 2020; 83(4):1150-9.
Bonometti R, Sacchi M, Stobbione P, et al. The first case of systemic lupus erythematosus (sle) triggered by Covid-19 infection. Eur Rev. Med. Pharmacol. Sci. 2020; 24(18).
Favas T, Chaurasia R, Chakravarty K, et al. Neurologic manifestations of Covid-19: A systematic review and meta-analysis of proportions. Neurol Sci 2020; 41(12):3437-3470.
Mao L, Jin H, Wang M, et al. Neurologic manifestations of hospitalized patients with Coronavirus disease 2019 in Wuhan, China. JAMA Neurol 2020; 77(6):683.
Samaranayake LP, Fakhruddin KS, Panduwawala C. Sudden onset acute loss of taste and smell in coronavirus disease 2019 (Covid-19): A systematic review. Acta Odontol. Scand. 2020; 78(6):467-73.
Saniasiaya J. Hearing loss in SARS-CoV-2: What do we know? Ear Nose Throat J 2021; 100:152S-154S.
Lee K, Yusof K, Ching S, et al. Stroke and novel coronavirus infection in humans: A systematic review and meta- analysis. Front. Neurol. 2020;11.
Goh C, Tan Y, Leow A, et al. Cerebral venous thrombosis in patients with Covid-19 infection: A case series and systematic review. J. Stroke Cerebrovasc. Dis. 2020; 29(12):105379.
Bareeqa S, Ahmed S, Samar S, et al. Prevalence of depression anxiety and stress in china during Covid-19 pandemic: A systematic review with meta-analysis. Int. J. Psychiatry Med. 2020; 56(4):210-227.
Burhamah W, AlKhayyat A, Oroszlanyova M, et al. The psychological burden of the Covid-19 pandemic and associated lockdown measures: Experience from 4000 participants. J. Affect. Disord. 2020; 277:977–85.
Luo M, Guo L, Yu M, et al. The psychological and mental impact of coronavirus disease 2019(Covid-19) on medical staff and general public A systematic review and meta-analysis. Psychiatry Res. 2020; 291(113190):113190.
Zhu N, Zhang D, Wang, W, et al. A novel coronavirus from patients with pneumonia in china, 2019. N. Engl. J. Med. 2020; 382(8):727–33.
Pandey P, Agarwal S, Rajkumar. Lung pathology in Covid-19: A systematic review. Int. J. Appl. Basic Med. Res. 2020; 10(4):226.
Vitiello A, Ferrara F. Pharmacological agents to therapeutic treatment of cardiac injury caused by Covid-19. Life Sci. 2020; 262(118510):118510.
Andrade B, Rangel F, Santos N, et al. Repurposing approved drugs for guiding COVID-19 prophylaxis: A systematic review. Front Pharmacol 2020; 11.
Derechos de autor 2024 Katia Marisol Álvarez Díaz, Josué Luis Medina Estrada
Esta obra está bajo licencia internacional Creative Commons Reconocimiento 4.0.
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