Trombocitopenia inducida por heparinas, revisión de los mecanismos implicados, diagnóstico y manejo de un evento adverso complejo
Resumen
La trombocitopenia inducida por heparina (TIH) es un trastorno mediado por el sistema inmunitario causado por anticuerpos que reconocen complejos del factor plaquetario 4 y la heparina. La trombosis es una característica central e impredecible de este síndrome. A pesar del manejo óptimo, la morbilidad y la mortalidad de la enfermedad por trombosis siguen siendo altas. El estado hipercoagulable en TIH es biológicamente distinto de otros trastornos trombofílicos en que las complicaciones clínicas son directamente atribuibles a los complejos inmunes ultra grandes (CIUG) circulantes. En algunos individuos, los CIUG provocan respuestas procoagulantes celulares no controladas que culminan en trombosis. Hasta la fecha, los factores de riesgo clínicos y biológicos asociados con el riesgo trombótico en TIH siguen siendo esquivos. Esta revisión resumirá nuestra comprensión actual de la trombosis en TIH con atención a sus características clínicas, mecanismos celulares
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Derechos de autor 2022 Juan Sebastián Theran león ;Didier Karina Vera Quintero ;Paula Andrea Sánchez Quiñonez ;Barbara Yuliana Quintero Arevalo ;Stephania Julieth Nariño Anaya
Esta obra está bajo licencia internacional Creative Commons Reconocimiento 4.0.
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