Glifosato y cáncer: cuando la ciencia, la políticay la industria converge
Resumen
El glifosato es un herbicida de amplio espectro no selectivo y sistémico, cualquier planta puede absorberlo a través de sus tejidos. Su función consiste en destruir las plantas consideradas “malas yerbas” por los agricultores, es decir aquellas que “roban” espacio, luz, agua y nutrientes a la siembra. Otro de los usos del glifosato ha sido la aspersión aérea del químico para combatir cultivos de coca, amapola y marihuana, en países como Colombia, lo cual ha terminado por afectar la biodiversidad de áreas selváticas, al impactar más allá de las especies y los cultivos que son objetivo En el año 2015, la International Agency for Research on Cancer, concluyó que el glifosato es una sustancia probablemente cancerígena, a pesar de que algunas agencias, como la Autoridad Europea de Seguridad Alimentaria (EFSA), han dicho que no implica un riesgo y otras han minimizado los peligros, siempre y cuando se use “apropiadamente”, como la Agencia de Protección Ambiental de Estados Unidos (US EPA). En el presente artículo se revisan estas posturas a la luz de estudios científicos que han evaluado el impacto del uso del glifosato sobre la salud humana, especialmente como agente potencialmente cancerígeno.
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Andreotti G, Koutros S, Hofmann J, Sandler D, Lubin J, Lynch C, et al. (2018). Glyphosate Use and Cancer Incidence in the Agricultural Health Study. JNCI J Natl Cancer Inst, 110(August), 509–16.
Annett R, Habibi H, Hontela A. (2014). Impact of glyphosate and glyphosate‐based herbicides on the freshwater environment. Journal of Applied Toxicology, 34(5): 458-479.
Annett R, Habibi H, Hontela A. (2014). Impact of glyphosate and glyphosate-based herbicides on the freshwater environment. J Appl Toxicol, 34(5), 458–79.
Assessment Group on Glyphosate. (2021). Procedure and outcome of the draft Renewal Assessment Report on glyphosate. From: https://ec.europa.eu/food/system/files/2021-06/pesticides_aas_agg_report_202106.pdf. Accesed: april 2022
Benbrook C. (2019). How did the US EPA and IARC reach diametrically opposed conclusions on the genotoxicity of glyphosate-based herbicides? Environmental Sciences Europe, 31(1), 1-16.
Berry C. (2018). Glyphosate and cancer: the importance of the whole picture. Pest management science, 76(9), 2874-2877.
Bolognesi C, Carrasquilla G, Volpi S, Solomon K, Marshall E. (2009). Biomonitoring of Genotoxic Risk in Agricultural Workers from Five Colombian Regions: Association to Occupational Exposure to Glyphosate. J Toxicol Environ Heal Part A, 72(15–16), 986–97.
Borggaard O, Gimsing A. (2008). Fate of glyphosate in soil and the possibility of leaching to ground and surface waters: A review. Pest Manag Sci, 64(4), 441 -456.
Brusick D, Aardema M, Kier L, Kirkland D, Williams G. (2016). Genotoxicity Expert Panel review: weight of evidence evaluation of the genotoxicity of glyphosate, glyphosate-based formulations, and aminomethylphosphonic acid. Crit Rev Toxicol, 46(S1), 56–74.
Camacho A, Mejía D. (2017). The health consequences of aerial spraying illicit crops: The case of Colombia. J Health Econ, 54(1), 147–60.
Cerdeira A, Duke S. (2010). Effects of glyphosate-resistant crop cultivation on soil and water quality. GM Crops, 1(1), 16–24.
Chang E, Delzell E. (2016). Systematic review and meta-analysis of glyphosate exposure and risk of lymphohematopoietic cancers. J Environ Sci Health B, 51(6), 402–34.
Consejo Nacional de Estupefacientes. (2015). Resolución 006 de 2015. Diario Oficial N° 49530 junio 5 de 2015, pág 28.
Cox C. (1998). Glyphosate (roundup). Journal of pesticide reform, 18(3), 3-17.
De Roos A, Zahm S, Cantor K, Weisenburger D, Holmes F, Burmeister L, et al. (2003). Integrative assessment of multiple pesticides as risk factors for non-Hodgkin’s lymphoma among men. Occup Environ Med, 60(9), E11.
Dill G, Sammons R, Feng P, Kohn F, Kretzmer K, Mehrsheikh A, et al. (2010). Glyphosate: discovery, development, applications, and properties. Glyphosate resistance in crops and weeds: history, development, and management. Wilely, New Jersey, 2010. 1-14.
Donato F, Pira E, Ciocan C, Boffetta P. (2020). Exposure to glyphosate and risk of non-Hodgkin lymphoma and multiple myeloma: an updated meta-analysis. La Medicina del lavoro, 111(1), 63-73.
EFSA. (2015). Conclusion on the peer review of the pesticide risk assessment of the active substance glyphosate. EFSA J, 13(11), 4302.
EPA. (2016). Glyphosate Issue Paper: Evaluation of Carcinogenic Potential. From: https://www.epa.gov/sites/production/files/2016-09/documents/glyphosate_issue_paper_evaluation_of_carcincogenic_potential.pdf Accesed: april 2022.
European Chemicals Agency. Glyphosate. From: https://echa.europa.eu/hot-topics/glyphosate. Accesed: april 2022.
Food and Agriculture Organization of United Nations. (2016). Pesticides Residues in Food; Paper 231—Part I and Part II; Food and Agriculture Organization of United Nations: Rome, Italy.
Gomes M, Smedbol E, Chalifour A, Hénault-Ethier L, Labrecque M, Lepage L. (2014). Alteration of plant physiology by glyphosate and its by-product aminomethylphosphonic acid: an overview. J Exp Bot, 65(17), 4691–703.
Henao L, Montes C, Bernal M. (2015). Acute toxicity and sublethal effects of the mixture glyphosate (Roundup® Active) and Cosmo-Flux®411F to anuran embryos and tadpoles of four Colombian species. Rev Biol Trop, 63(1), 223–34.
IARC. (2015). Monographs, volume 112: Some organophosphate insecticides and herbicides: tetrachlorvinphos, parathion, malathion, diazinon and glyphosate. IARC Working Group. Lyon; 3–10. From: https://www.ncbi.nlm.nih.gov/books/NBK436774/pdf/Bookshelf_NBK436774.pdf. Accesed: april 2022.
IARC. Glyphosate. IARC, editor. Lyon, Fr; 2015. Available from: https://monographs.iarc.fr/wp-content/uploads/2018/06/mono112-10.pdf
Instituto Nacional de Cancerología. (2019). Linfoma No Hodgkin en Colombia, comportamiento epidemiológico en zonas expuestas y no expuestas a aspersión con glifosato, 2019.
Kabat G, Price W, Tarone R. (2021). On recent meta-analyses of exposure to glyphosate and risk of non-Hodgkin’s lymphoma in humans. Cancer Causes & Control, 32(1), 1-6.
Kruger M, Schrodl W, Pedersen I, Shehata A. (2014). Detection of glyphosate in malformed piglets. J Environ Anal Toxicol, 4(230), 4:5.
La Cecilia D, Maggi F. (2018). Analysis of glyphosate degradation in a soil microcosm. Environmental Pollution, 233(1), 201-207.
Lane M, Lorenz N, Saxena J, Ramsier C, Dick R. (2012). The effect of glyphosate on soil microbial activity, microbial community structure, and soil potassium. Pedobiología, 55(6), 335–342.
Mattiuzzi C, Lippi G. (2019). Current cancer epidemiology. Journal of epidemiology and global health, 9(4), 217-222.
Mejia D, Restrepo P. (2016). The economics of the war on illegal drug production and trafficking. Journal of Economic Behavior & Organization, 126(1), 255-275.
Ministerio de Ambiente Vivienda y Desarrollo Territorial. (2003). Resolución 1054 de 2003. Por la cual se modifica un Plan de Manejo Ambiental y se toman otras determinaciones. From: http://www.suin-juriscol.gov.co/viewDocument.asp?ruta=Resolucion/30031785. Accesed: april 2022.
Ministerio de Medio Ambiente. (2001). Plan Manejo Ambiental. Resolución 1065 de 2001. From: http://www.suin-juriscol.gov.co/viewDocument.asp?ruta=Resolucion/30031786. Accesed: april 2022.
Monroy C, Cortés A, Sicard D, De Restrepo H. (2005). Citotoxicidad y genotoxicidad en células humanas expuestas in vitro a glifosato. Biomédica, 25(3), 335-345.
Myers J, Antoniou M, Blumberg B, Carroll L, Colborn T, Everett L, Benbrook C. (2016). Concerns over use of glyphosate-based herbicides and risks associated with exposures: a consensus statement. Environmental Health, 15(1), 1-13.
Nguyen D, Rose M, Rose T, Morris S, Van Zwieten L. (2016). Impact of glyphosate on soil microbial biomass and respiration: a meta-analysis. Soil Biology and Biochemistry, 92(1), 50-57.
Nodo Sao (2020). Pronunciamiento Nodo SAO Colombia Fracking y Glifosato en Colombia: cuando las políticas públicas se toman en contra de la evidencia científica. From: https://www.las2orillas.co/fracking-y-glifosato-en-colombia-cuando-las-politicas-publicas-se-toman-en-contra-de-la-evidencia-cientifica/#:~:text=CONVERSACIONESFracking%20y%20glifosato%20en%20Colombia%3A%20cuando%20las%20pol%C3%ADticas%20p%C3%BAblicas%20se,contra%20de%20la%20evidencia%20cient%C3%ADfica&text=En%20mayo%20de%202015%2C%20el,en%20diferentes%20zonas%20del%20pa%C3%ADs. Accesed: april 2022.
Ostera J, Malanga G Puntarulo S. (2016). An update on the effects of glyphosate on the oxidative state in biological systems. Biotecnia, 18(2), 3-10.
Paganelli A, Gnazzo V, Acosta H, Lopez S, Carrasco E. (2010). Glyphosate-based herbicides produce teratogenic effects on vertebrates by impairing retinoic acid signaling. Chem Res Toxicol, 23(10), 1586–95.
Paz y Miño C, Sánchez M, Arévalo M, Muñoz M, Witte T, De la Carrera G, Leone P. (2007). Evaluation of DNA damage in an Ecuadorian population exposed to glyphosate. Genetics and Molecular Biology, 30(2), 456-460.
Rothman K, Greenland S. (2005). Causation and causal inference in epidemiology. Am J Public Health. 95(S1), S144–50.
Schinasi L, Leon M. (2014). Non-Hodgkin lymphoma and occupational exposure to agricultural pesticide chemical groups and active ingredients: a systematic review and meta-analysis. International journal of environmental research and public health, 11(4), 4449-4527.
Shehata A, Schrodl W, Aldin A, Hafez H, Kruger M. (2013). The effect of glyphosate on potential pathogens and beneficial members of poultry microbiota in vitro. Curr Microbiol, 66(4), 350–8.
Smedbol E, Lucotte M, Maccario S, Gomes M, Paquet S, Moingt M, et al. (2019). Glyphosate and aminomethylphosphonic acid content in glyphosate-resistant soybean leaves, stems, and roots and associated phytotoxicity following a single glyphosate-based herbicide application. Journal of agricultural and food chemistry, 67(22), 6133-6142.
Solomon K, Anadon A, Carrasquilla G, Cerdeira A, Marshall J, Sanin L. (2007). Coca and poppy eradication in Colombia: environmental and human health assessment of aerially applied glyphosate. Rev Environ Contam Toxicol, 190(1), 43–125.
Szekacs A, Darvas B. (2012). Forty years with Glyphosate. In: Herbicides - Properties, Synthesis and Control of Weeds. Edited by Nagib Hasaneen M, vol. From: http://www.intechopen.com/books/herbicides-properties-synthesis-and-control-of-weeds/forty-years-with-glyphosate. : InTech, doi: 10.5772/32491; Accessed: November 2022.
Tarazona J, Tiramani M, Reich H, Pfeil R, Istace F, Crivellente F. (2017). Glyphosate toxicity and carcinogenicity: a review of the scientific basis of the European Union assessment and its differences with IARC. Archives of toxicology, 91(8), 2723-2743.
Torretta V, Katsoyiannis I, Viotti P, Rada E. (2018). Critical review of the effects of glyphosate exposure to the environment and humans through the food supply chain. Sustainability, 10(4), 950.
Van Bruggen A, He M, Shin K, Mai V, Jeong K, Finckh M, et al. (2018). Environmental and health effects of the herbicide glyphosate. Sci Total Environ. 2018;616–617, 255–68.
Varona M, Henao G, Díaz S, Lancheros A, Murcia Á, Rodríguez N, et al. (2009). Evaluación de los efectos del glifosato y otros plaguicidas en la salud humana en zonas objeto del programa de erradicación de cultivos ilícitos. Biomédica, 29(3), 456-475.
Vereecken H. (2005). Mobility and leaching of glyphosate: A review. Pest Manag Sci, 61(12), 1139–1151.
World Health Organization, United Nations Environment Programme, the International Labour Organization (1994). Glyphosate. Environmental Health Criteria #159. Geneva, Switzerland, WHO.11-13.
Zhang L, Rana I, Shaffer R, Taioli E, Sheppard L. (2019). Exposure to glyphosate-based herbicides and risk for non-Hodgkin lymphoma: a meta-analysis and supporting evidence. Mutation Research/Reviews in Mutation Research, 781(1), 186-206.
Derechos de autor 2023 Rusvelt Vargas Moranth;Lilibeth Llinás Burgos;Esteban Vargas Alcocer;Adalgisa Alcocer Olaciregui;Adalberto Llinás Delgado
Esta obra está bajo licencia internacional Creative Commons Reconocimiento 4.0.
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