Nuevos avances farmacologicos y no farmacologicos en diabetes tipo 1, revision de las nuevas fronteras y retos en una enfermedad endocrina compleja

Resumen

 La diabetes tipo 1 (DT1) es causada por la destrucción autoinmune de las células β productoras de insulina ubicadas en el páncreas endocrino en áreas conocidas como islotes de Langerhans. El estándar de atención actual para la DT1 es la terapia de reemplazo de insulina exógena. Los desarrollos recientes en este campo incluyen el sistema híbrido de circuito cerrado para la administración de insulina regulada e insulinas de acción prolongada. Los estudios clínicos sobre predicción y prevención de complicaciones asociadas a la diabetes han demostrado la importancia del tratamiento temprano y el control de la glucosa para reducir el riesgo de desarrollar complicaciones diabéticas. El trasplante de islotes primarios ofrece un enfoque eficaz para el tratamiento de pacientes con DT1. Sin embargo, esta estrategia se ve obstaculizada por desafíos como la disponibilidad limitada de islotes, la muerte extensa de las células de los islotes, y mal injerto vascular de los islotes después del trasplante. En consecuencia, actualmente se están realizando esfuerzos considerables para mejorar la eficiencia del trasplante de islotes mediante el aprovechamiento de las acciones beneficiosas de las células madre. Esta revisión brindará una descripción general de las opciones terapéuticas actualmente disponibles para la DT1 y analizará la creciente evidencia que respalda el uso de enfoques con células madre para mejorar los resultados terapeuticos

Palabras clave: diabetes tipo 1, terapia con insulina, trasplante de islotes, inmunoterapias, células madre mesenquimales, células madre pluripotentes inducidas, células formadoras de colonias endoteliales

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Publicado
2023-01-17
Cómo citar
Theran león , J. S., Dulcey Sarmiento, L. A., Esteban Badillo, L. Y., Nariño Anaya , S. J., Maiguel Cardenas, R. C., & Trujillo Ávila , H. X. (2023). Nuevos avances farmacologicos y no farmacologicos en diabetes tipo 1, revision de las nuevas fronteras y retos en una enfermedad endocrina compleja. Ciencia Latina Revista Científica Multidisciplinar, 7(1), 83-113. https://doi.org/10.37811/cl_rcm.v7i1.4380
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